pp32/I-1PP2A negatively regulates the Raf-1/MEK/ERK pathway
pp32/I-1PP2A negatively regulates the Raf-1/MEK/ERK pathway
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DOI：
10.1016/j.canlet.2004.11.026
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发表时间：
2005-08-26
期刊：
影响因子：
9.7
通讯作者：
Shima, H
中科院分区：
文献类型：
--
作者：
Fukukawa, C;Tanuma, N;Shima, H
在这项研究中，我们专注于pp 32/1-1（PP 2A）（pp 32）与Raf-MEK-ERK信号通路的潜在相互作用。我们发现过表达的pp 32抑制Raf-1激活，从而下调ERK激活水平。Raf-1的这种抑制需要pp 32的C末端一半。相反，通过siRNA敲低PP 32增强ERK和MEK活化。总之，我们认为pp 32的肿瘤抑制作用至少部分是通过下调Raf-MEK-ERK信号通路介导的。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
In this study, we focus on the potential interaction of pp32/1-1(PP2A) (pp32) with the Raf-MEK-ERK signaling pathway. We show that overexpressed pp32 suppresses Raf-1 activation, thereby downregulating the level of ERK activation. This suppression of Raf-1 requires the C-terminal half of pp32. Conversely, knock-down of PP32 by siRNA enhances ERK and MEK activations. Taken together, we propose that tumor-suppression by pp32 is, at least in part, mediated by downregulation of the Raf-MEK-ERK signaling pathway. (C) 2004 Elsevier Ireland Ltd. All rights reserved.