Prevalence of psychiatric disorders in an onset cohort of adults with type 1 diabetes
Prevalence of psychiatric disorders in an onset cohort of adults with type 1 diabetes
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DOI：
10.1002/dmrr.374
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发表时间：
2003-05-01
影响因子：
8
通讯作者：
Hoffmann, SO
中科院分区：
文献类型：
--
作者：
Petrak, F;Hardt, J;Hoffmann, SO
背景先前的研究表明，成人1型糖尿病患者中精神障碍的患病率很高。我们研究的目的是确定新诊断为1型糖尿病的成年人在身体疾病开始时是否已经有较高的精神疾病发生率。方法从12家医院连续招募313例初诊成人I型糖尿病住院患者（年龄17 ~ 40岁）。一个由2046名年龄相仿的人组成的全国代表性人口样本作为参照组。两组的精神疾病均采用结构化访谈进行测量，并根据DSM-IV提供诊断。结果样本中精神障碍的点患病率为12.5%。最常见的情况是焦虑和情感障碍。1型糖尿病患者的重度抑郁发作率是对照组的两倍（5.8% vs 2.7%, p < 0.003；校正了混杂因素）。除此之外，与德国普通人群相比，糖尿病样本中精神疾病的患病率并没有显著增加。结论新发1型糖尿病患者重性抑郁发作率是整体人群的两倍。然而，新诊断的1型糖尿病患者比一般人群有更多精神疾病的假设并未得到证实。版权所有：John Wiley Sons， Ltd。
Background Previous studies indicate a high prevalence of psychiatric disorders in adults with type 1 diabetes mellitus. The aim of our study was to determine if newly diagnosed adults with type I diabetes already have an elevated rate of psychiatric disorders at the beginning of their physical illness.Methods The authors consecutively recruited 313 newly diagnosed, adult inpatients with type I diabetes (age 17-40 years) from 12 hospitals. A national, representative population sample of 2046 persons of a similar age range served as the reference group. Psychiatric disorders were measured in both groups using structured interviews that provided diagnoses according to DSM-IV.Results There was a point prevalence of 12.5% for psychiatric disorders in the sample. The most frequent conditions were anxiety and affective disorders. Subjects with type 1 diabetes demonstrated a rate of major depressive episodes twice that of the reference group (5.8% vs 2.7%, p < 0.003; corrected for confounders). Apart from this finding, there was no significantly increased prevalence of psychiatric disorders in the diabetes sample as compared to the general German population.Conclusion The rate of major depressive episodes in the new onset cohort of type 1 diabetes patients was double that of the population as a whole. However, the hypothesis, that newly diagnosed type 1 diabetes patients have more psychiatric disorders than the general population, was not confirmed. Copyright (C) 2003 John Wiley Sons, Ltd.