The function of e-cadherin in stem cell pluripotency and self-renewal.
The function of e-cadherin in stem cell pluripotency and self-renewal.
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DOI：
10.3390/genes2010229
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发表时间：
2011-02-25
期刊：
影响因子：
3.5
通讯作者：
Ward CM
中科院分区：
文献类型：
--
作者：
Soncin F;Ward CM
胚胎干（ES）和诱导多能干（iPS）细胞可以在适当的条件下无限期生长，同时保留分化为代表三个初级胚层的细胞的能力。此类细胞有可能为多种疾病和病症提供治疗选择，并提供用于阐明发育和疾病机制的模型系统，从而彻底改变医学。近年来，E-钙粘蛋白在调节 ES 和 iPS 细胞多能和自我更新信号通路中的功能的证据已经出现。在这篇综述中，我们讨论了 E-钙粘蛋白及其相互作用伙伴在发育和疾病背景下的功能。然后我们描述了相关文献，强调了 E-钙粘蛋白在建立和维持 ES 和 iPS 细胞的多能和自我更新特性中的功能。此外，我们提供的实验数据表明，将人 ES 细胞暴露于 E-钙粘蛋白中和抗体 SHE78.7 可以在缺乏 FGF2 补充培养基的情况下培养这些细胞。
Embryonic stem (ES) and induced-pluripotent stem (iPS) cells can be grown indefinitely under appropriate conditions whilst retaining the ability to differentiate to cells representative of the three primary germ layers. Such cells have the potential to revolutionize medicine by offering treatment options for a wide range of diseases and disorders as well as providing a model system for elucidating mechanisms involved in development and disease. In recent years, evidence for the function of E-cadherin in regulating pluripotent and self-renewal signaling pathways in ES and iPS cells has emerged. In this review, we discuss the function of E-cadherin and its interacting partners in the context of development and disease. We then describe relevant literature highlighting the function of E-cadherin in establishing and maintaining pluripotent and self-renewal properties of ES and iPS cells. In addition, we present experimental data demonstrating that exposure of human ES cells to the E-cadherin neutralizing antibody SHE78.7 allows culture of these cells in the absence of FGF2-supplemented medium.
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