Speckle Tracking Echocardiography Assessment of Global and Regional Contraction Dysfunction in the Mice Model of Pressure Overload
Speckle Tracking Echocardiography Assessment of Global and Regional Contraction Dysfunction in the Mice Model of Pressure Overload
复制标题
斑点追踪超声心动图评估压力过载小鼠模型中的整体和区域收缩功能障碍
DOI：
10.1007/s11596-015-1423-4
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发表时间：
2015-04-01
影响因子：
--
通讯作者：
Zhang, Cun-tai
中科院分区：
文献类型：
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作者：
Wang, Guan;Zhang, Le;Zhang, Cun-tai
斑点追踪超声心动图（STE）已被应用于评价心脏收缩功能障碍。然而，关于心肌肥厚和心力衰竭过程中整体和局部STE参数变化的研究较少。本研究应用STE技术评价压力超负荷小鼠心力衰竭和心肌肥厚时的整体和局部心功能。用25号（G）或27 G针对成年小鼠进行轻度或重度主动脉结扎。术后分别对假手术组（n=10）、轻度经主动脉缩窄（TAB）组（n=14）和重度TAB组（n=10）进行STE和常规超声心动图检查，观察8周。结果表明，重度TAB组小鼠左室短轴缩短率（FS）、左室质量（LV）和左室舒张末期内径（LVEDD）均发生显著变化（P0.05）。STE分析显示，与假手术组和轻度TAB组相比，重度TAB组的纵向应变（LS）显著降低（P
Speckle tracking echocardiography (STE) has been applied to the evaluation of cardiac contraction dysfunction. However, there were few studies on alteration of global and regional STE parameters in the process of myocardial hypertrophy and heart failure. In this study, STE was applied to evaluate the global and regional cardiac function under heart failure and hypertrophy in the mice model of pressure overload. Adult mice were subjected to mild or severe aortic banding with a 25 Gauge (G) or 27 G needle. After surgery, STE and conventional echocardiography were used in the sham group (n=10), mild trans-aortic banding (TAB) group (n=14) and severe TAB group (n=10) for 8 weeks. The results showed that the mice subjected to severe TAB showed a significant change in fractional shortening (FS), left ventricular (LV) mass, and left ventricular end diastolic diameter (LVEDD) (P0.05 for both). STE analysis revealed that longitudinal strain (LS) was significantly decreased in the severe TAB group as compared with the sham and mild TAB groups (P