Vaccinomics, the new road to tick vaccines
Vaccinomics, the new road to tick vaccines
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DOI：
10.1016/j.vaccine.2013.10.049
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发表时间：
2013-12-05
期刊：
影响因子：
5.5
通讯作者：
Merino, Octavio
中科院分区：
文献类型：
--
作者：
de la Fuente, Jose;Merino, Octavio
蜱虫对全世界人类和动物健康构成威胁。蜱被认为是世界范围内仅次于蚊子的第二大人类疾病媒介，是影响全球养牛业的最重要的疾病媒介，也是影响宠物的疾病的重要媒介。蜱疫苗是一种经济有效且环境友好的替代方案，可通过控制媒介感染和减少病原体感染和传播来预防蜱传疾病。这些前提强调需要以更有效的方式开发改进的蜱疫苗。在这种背景下，从蜱宿主-病原体分子相互作用的研究开始，到疫苗配方的表征和验证结束，疫苗组学方法将极大地促进蜱传疾病改良疫苗的开发。用于控制蜱虫感染和病原体感染和传播的新候选疫苗抗原的发现需要开发有效的筛选平台和算法，以便分析和验证蜱虫研究的系统生物学方法产生的数据。影响蜱虫感染和病原体传播的蜱疫苗可用于对处于危险中的人类和动物群体以及储存物种进行疫苗接种，以减少宿主与蜱虫的接触，同时减少受感染蜱虫的数量及其传播影响全世界人类和动物健康的病原体的能力。 (C) 2013 Elsevier Ltd. 保留所有权利。
Ticks are a threat to human and animal health worldwide. Ticks are considered to be second worldwide to mosquitoes as vectors of human diseases, the most important vectors of diseases that affect cattle industry worldwide and important vectors of diseases affecting pets. Tick vaccines are a cost-effective and environmentally friendly alternative to protect against tick-borne diseases through the control of vector infestations and reducing pathogen infection and transmission. These premises stress the need for developing improved tick vaccines in a more efficient way. In this context, development of improved vaccines for tick-borne diseases will be greatly enhanced by vaccinomics approaches starting from the study of tick-host-pathogen molecular interactions and ending in the characterization and validation of vaccine formulations. The discovery of new candidate vaccine antigens for the control of tick infestations and pathogen infection and transmission requires the development of effective screening platforms and algorithms that allow the analysis and validation of data produced by systems biology approaches to tick research. Tick vaccines that affect both tick infestations and pathogen transmission could be used to vaccinate human and animal populations at risk and reservoir species to reduce host exposure to ticks while reducing the number of infected ticks and their vectorial capacity for pathogens that affect human and animal health worldwide. (C) 2013 Elsevier Ltd. All rights reserved.