Effects of ethanol intake and ethanol withdrawal on free-running circadian activity rhythms in rats
Effects of ethanol intake and ethanol withdrawal on free-running circadian activity rhythms in rats
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DOI：
10.1016/j.physbeh.2005.01.016
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发表时间：
2005-03-31
影响因子：
2.9
通讯作者：
Logan, RW
中科院分区：
文献类型：
--
作者：
Rosenwasser, AM;Fecteau, ME;Logan, RW
在人类酗酒者和实验动物中，长期饮酒和戒酒与日常(昼夜节律)生物节律的戏剧性破坏有关。然而，这些观察结果在多大程度上是由于药物对潜在的昼夜节律起搏器的影响尚不清楚，因为在自由奔跑的条件下，没有进行过人体研究，也很少进行动物研究。在本研究中，监测了大鼠在暴露于10%或20%乙醇溶液作为唯一饮水液之前、期间和之后的自由奔跑昼夜活动(轮跑)节律。在个体中，在酒精摄入期间观察到自由奔跑时间的延长和缩短，终止治疗会导致回到基线或加剧最初的酒精效应。这些可变效应似乎既与乙醇浓度有关，也与基线期间的个体差异有关，因此，基线期间相对较短的自由运行时期与酒精暴露期间较大的周期延长有关。乙醇对自由运行期的这些双向影响通常与之前看到的其他精神活性药物的影响相似，包括抗抑郁药。这项研究的结果表明，乙醇影响心脏起搏器，人类酗酒者的时间生物学紊乱可能部分是由于昼夜起搏器调节的改变。(C)2005 Elsevier Inc.保留所有权利。
Chronic alcohol intake and alcohol withdrawal are associated with dramatic disruptions of daily (circadian) biological rhythms in both human alcoholics and experimental animals. The extent to which these observations are due to pharmacological effects on the underlying circadian pacemaker is not known, however, since no human studies and very few animal studies have been conducted under free-running conditions. In the present study, free-running circadian activity (wheel-running) rhythms of rats were monitored before, during and after exposure to either 10% or 20% ethanol solution as the only drinking fluid. Across individuals, both lengthening and shortening of free-running period were observed during ethanol intake, and treatment termination led to either a return to baseline or to an exacerbation of the original ethanol effect. These variable effects appeared to be related to both ethanol concentration and to individual differences in baseline period, such that relatively short free-running period during baseline was associated with greater period-lengthening during ethanol exposure. These bidirectional affects of ethanol on free-running period are generally similar to effects seen previously with other psychoactive drugs, including antidepressants. The results of this study indicate that ethanol influences the cireadian pacemaker, and that the chronobiological disruptions seen in human alcoholics may be due, in part, to alterations in circadian pacemaker regulation. (c) 2005 Elsevier Inc. All rights reserved.