Optimization of Slow-Release Tablet Formulations: Containing Montmorillonite I. Properties of Tablets
Optimization of Slow-Release Tablet Formulations: Containing Montmorillonite I. Properties of Tablets
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含蒙脱石缓释片配方优化一、片剂性能
DOI：
10.3109/03639048009068711
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发表时间：
1980
影响因子：
3.4
通讯作者：
M. R. Harris
中科院分区：
文献类型：
--
作者：
J. Mcginity;M. R. Harris
含20%。磺胺噻唑钠和30%。通过直接压缩技术制备硅酸镁铝。溶出度研究表明，片剂硬度对药物从片剂中释放的影响可忽略不计。在溶解过程中，粘土缓慢溶胀，在片剂基质周围形成凝胶状水合层。在更快的搅拌速度下，溶出篮和片剂之间的摩擦迅速去除了水合边界区域，导致磺胺的溶出速率更快。去离子水中的溶解速率比稀酸中快，因为粘土在较高的坑中更容易水合。
AbstractSlow-release tablets containing 20%. sodium sul fathiazole and 30%. magnesium aluminum silicate were prepared by direct compression techniques. Dissolution studies indicated that tablet hardness exerted a negligible influence on drug release from the tablets. During the dissolution process the clay slowly swelled to form a gelatinous hydrated layer around the tablet matrix. At faster stirring speeds, friction between the dissolution basket and the tablet rapidly removed the hydrated boundary region and resulted in a more rapid dissolution rate of the sulfonamide. Faster rates of dissolution were seen in deionized water than in dilute acid since the clay hydrated more readily at the higher pit.