Mathematik in den Naturwissenschaften Leipzig How cellular movement determines the collective force generated by the Dictyostelium discoideum slug
Mathematik in den Naturwissenschaften Leipzig How cellular movement determines the collective force generated by the Dictyostelium discoideum slug
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发表时间：
2004
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通讯作者：
J. Dallon;H. Othmer
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作者：
J. Dallon;H. Othmer
生物组织中细胞的集体运动是如何起源于一群个体的行为的，每个个体都对它从邻居那里接收到的化学和机械信号做出反应，仍然知之甚少。在这里，我们研究这个问题的一个特定的系统，蛞蝓阶段的细胞黏菌Dictyosteelium discoideum。我们研究如何在迁移的蛞蝓内部的细胞可以有效地传递应力的基板，从而有助于整体动力。理论分析表明，必要条件的行为，个别细胞，计算结果揭示了实验结果有关的总力的迁移段塞。该模型预测，只有细胞与基板接触有助于段塞的平移运动。由于该模型并不是专门基于盘基网柄菌细胞的机械特性，因此结果表明这种行为会在许多发育中的系统中发现。
How the collective motion of cells in a biological tissue originates in the behavior of a collection of individuals, each of which responds to the chemical and mechanical signals it receives from neighbors, is still poorly understood. Here we study this question for a particular system, the slug stage of the cellular slime mold Dictyostelium discoideum. We investigate how cells in the interior of a migrating slug can effectively transmit stress to the substrate and thereby contribute to the overall motive force. Theoretical analysis suggests necessary conditions on the behavior of individual cells, and computational results shed light on experimental results concerning the total force exerted by a migrating slug. The model predicts that only cells in contact with the substrate contribute to the translational motion of the slug. Since the model is not based specifically on the mechanical properties of Dictyostelium discoideum cells, the results suggest that this behavior will be found in many developing systems.