Hagfish leukocytes express a paired receptor family with a variable domain resembling those of antigen receptors
Hagfish leukocytes express a paired receptor family with a variable domain resembling those of antigen receptors
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DOI：
10.4049/jimmunol.174.5.2885
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发表时间：
2005-03-01
影响因子：
4.4
通讯作者：
Kasahara, M
中科院分区：
文献类型：
--
作者：
Suzuki, T;Shin, T;Kasahara, M
有颌脊椎动物具有重组V结构域的TCR和BCR。相比之下，以盲鳗和七鳃鳗为代表的无颌脊椎动物显然缺乏这种受体。在这项研究中，我们描述了一个盲鳗基因家族，它携带一个类似于TCR/BCR的v型结构域。这个多基因家族，我们称之为agnathan配对受体类似Ag受体（APAR），在白细胞中表达，预计编码一组膜糖蛋白，其组织具有配对igg样受体的特征，包括激活和抑制形式。APAR的V型结构域有一个J区，其V区和J区编码在一个外显子上。因此，APAR是新兴的具有TCR/ bcr样v型结构域的多样化先天免疫型受体家族的一员，具有许多原始TCR/ bcr样受体的特征。APAR的细胞外结构域可能来自于一个v型结构域，该结构域被认为在颚脊椎动物谱系中获得了重组信号序列。
Jawed vertebrates are equipped with TCR and BCR with the capacity to rearrange their V domains. By contrast, jawless vertebrates, represented by hagfish and lampreys, apparently lack such receptors. We describe in this study a family of hagfish genes carrying a single V-type domain resembling those of TCR/BCR. This multigene family, which we call agnathan paired receptors resembling Ag receptors (APAR), is expressed in leukocytes and predicted to encode a group of membrane glycoproteins with organizations characteristic of paired Ig-like receptors, consisting of activating and inhibitory forms. APAR has a J region in its V-type domain, and its V and J regions are encoded in a single exon. Thus, APAR is a member of the emerging families of diversified, innate immune-type receptors with TCR/BCR-like V-type domains and has many of the features expected for a primordial TCR/BCR-like receptor. The extracellular domain of APAR may be descended from a V-type domain postulated to have acquired recombination signal sequences in a jawed vertebrate lineage.