Cherenkov Video Imaging Allows for the First Visualization of Radiation Therapy in Real Time
Cherenkov Video Imaging Allows for the First Visualization of Radiation Therapy in Real Time
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DOI：
10.1016/j.ijrobp.2014.01.046
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发表时间：
2014-07-01
影响因子：
7
通讯作者：
Pogue, Brian W.
中科院分区：
文献类型：
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作者：
Jarvis, Lesley A.;Zhang, Rongxiao;Pogue, Brian W.
目的：为了确定切伦科夫光成像是否可以可视化放疗在真实的时间在乳腺radiationtherapy.Methods和Materials：一个增强的电荷耦合器件（CCD）相机同步到3.25 μ s的放射脉冲的临床直线加速器与增强器设置× 100。连续采集切伦科夫图像（2.8帧/秒），每帧累积100个辐射脉冲（大约5个显示器单元）。有史以来创建的第一个患者图像用于说明切伦科夫发射可以在乳腺放射治疗的典型条件下可视化为视频，即使是复杂的治疗计划，混合能量，和调制的治疗场。生成的图像与患者接受的浅表剂量相关，并可能与导致皮肤反应的位置相关。主要血管在图像中可见，提供了将这些用作生物标志以提高几何精度的可能性。该系统检测放射治疗管理不善，这可能会导致硬件故障或患者定位设置错误，在个别fractions.Conclusions：Cherenkoscopy是一种独特的方法，用于可视化的表面剂量，导致实时质量控制的潜力。我们建议，该系统可以检测放射治疗错误在日常的临床实践中，当这些错误可以得到纠正，从而提高放射治疗的安全性和质量。(C)2014年爱思唯尔公司
Purpose: To determine whether Cherenkov light imaging can visualize radiation therapy in real time during breast radiation therapy.Methods and Materials: An intensified charge-coupled device (CCD) camera was synchronized to the 3.25-mu s radiation pulses of the clinical linear accelerator with the intensifier set x 100. Cherenkov images were acquired continuously (2.8 frames/s) during fractionated whole breast irradiation with each frame an accumulation of 100 radiation pulses (approximately 5 monitor units).Results: The first patient images ever created are used to illustrate that Cherenkov emission can be visualized as a video during conditions typical for breast radiation therapy, even with complex treatment plans, mixed energies, and modulated treatment fields. Images were generated correlating to the superficial dose received by the patient and potentially the location of the resulting skin reactions. Major blood vessels are visible in the image, providing the potential to use these as biological landmarks for improved geometric accuracy. The potential for this system to detect radiation therapy misadministrations, which can result from hardware malfunction or patient positioning setup errors during individual fractions, is shown.Conclusions: Cherenkoscopy is a unique method for visualizing surface dose resulting in real-time quality control. We propose that this system could detect radiation therapy errors in everyday clinical practice at a time when these errors can be corrected to result in improved safety and quality of radiation therapy. (C) 2014 Elsevier Inc.