Pathologic changes in the non-carcinomatous epithelium of the gallbladder in patients with a relatively long common channel
Pathologic changes in the non-carcinomatous epithelium of the gallbladder in patients with a relatively long common channel
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DOI：
10.1016/s0016-5107(04)01290-8
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发表时间：
2004-07-01
影响因子：
7.7
通讯作者：
Yamaguchi, T
中科院分区：
文献类型：
--
作者：
Kamisawa, T;Funata, N;Yamaguchi, T
背景资料：除了胰胆管合流异常，一个相对较长的共同渠道和胆囊carcinoma之间的关系是unknown.Methods：为了本研究的目的，胰胆管高汇合被定义为一个共同的渠道，是6毫米或更长的长度，连同闭塞的胰腺和胆管之间的沟通在括约肌收缩。在3300例接受ERCP的连续患者中，分别有69例（2.1%）和54例（1.6%）检测到胰胆管合流异常和胰胆管高度汇合。结果：胰胆管高度汇合和胰胆管合流异常无胆管扩张者胆囊上皮细胞Ki-67标记指数明显高于无胰胆管合流异常和胰胆管合流异常者胆囊上皮细胞Ki-67标记指数（P < 0.05），而无胰胆管合流异常者胆囊上皮细胞Ki-67标记指数明显高于无胰胆管合流异常和胰胆管合流异常者（P < 0.05）。
Background: Except for pancreaticobiliary maljunction, the relationship between a relatively long common channel and gallbladder carcinoma is unknown.Methods: For purposes of this study, a high confluence of pancreaticobiliary ducts was defined as a common channel that is 6 mm or greater in length, together with occlusion of the communication between the pancreatic and bile ducts during sphincter contraction. Pancreaticobiliary maljunction and high confluence of the pancreaticobiliary ducts were detected in 69 (2.1%) and 54 (1.6%), respectively, of 3300 consecutive patients who underwent ERCP. Proliferation activity and genetic alteration were examined in the non-carcinomatous epithelium of the gallbladder in patients with these two radiographic findings at ERCP.Results: The Ki-67 labeling index in the epithelium in cases of a high confluence of the pancreaticobiliary ducts and pancreaticobiliary maljunction without biliary dilatation was significantly greater than that in cases of gallbladder carcinoma without these anomalies (p