TNF-α, soluble TNF receptor and interleukin-6 plasma levels in the general population
TNF-α, soluble TNF receptor and interleukin-6 plasma levels in the general population
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DOI：
10.1684/ecn.2006.0037
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发表时间：
2006-09-01
影响因子：
2.8
通讯作者：
Pollmaecher, Thomas
中科院分区：
文献类型：
--
作者：
Himmerich, Hubertus;Fulda, Stephany;Pollmaecher, Thomas
细胞因子肿瘤坏死因子- α (TNF- α)、可溶性TNF受体p55和p75以及白细胞介素6 （IL-6）参与宿主对多种微生物制剂的防御、炎症过程和体重调节。在目前的研究中，我们试图评估年龄、性别、吸烟和体重指数对从巴伐利亚人群中随机选择的550多名成人受试者血浆中TNF- α、TNF受体和IL-6水平的影响。细胞因子参数均不符合正态分布，分布均有显著偏态。细胞因子血浆水平随年龄的增长而显著升高，性别对血浆水平的影响相对较弱。血浆TNF- α、TNF受体和IL-6水平与BMI显著相关。该研究提供了对随机选择的研究样本中影响细胞因子水平的因素的见解。
The cytokines tumor necrosis factor-alpha (TNF-alpha), soluble TNF receptors p55 and p75, and interleukin 6 (IL-6) are involved in host defense against several microbiological agents, in the process of inflammation and also in body weight regulation. In the present study, we sought to assess the influence of age, gender, smoking, and body mass index on plasma levels of TNF-alpha, TNF receptors, and IL-6 in more than 550 adult subjects randomly selected from the Bavarian population. None of the cytokine parameters had a normal distribution and all distributions were significantly skewed. The cytokine plasma levels investigated increased significantly with age, while gender had a relatively weaker influence on the plasma levels. Plasma levels of TNF-alpha, TNF receptors, and IL-6 correlated significantly with the BMI. The study provides insights into factors influencing the cytokine levels investigated in a randomly chosen study sample.