Evaluation of the fibulin 5 gene polymorphism as a factor related to the occurrence of pelvic organ prolapse
Evaluation of the fibulin 5 gene polymorphism as a factor related to the occurrence of pelvic organ prolapse
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DOI：
10.1590/1806-9282.66.5.680
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发表时间：
2020-05-01
期刊：
影响因子：
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通讯作者：
Oliveira, Emerson de
中科院分区：
文献类型：
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作者：
Paula, Marcus Vinicius Barbosa de;Lira Júnior, Marcos Antônio de Farias;Oliveira, Emerson de
目的：盆腔器官脱垂（POP）是我们人群中非常常见的情况，可能导致患者生活质量显着下降。目前，我们正在寻找POPs发展的预测因素；因此，本研究旨在评估Fibulin 5多态性（FBLN5）是否与POP的发生相关。 方法：这是一项针对绝经后妇女的队列研究，按POP分期将其分为几组：POP O和I期（对照组）和POP III和IV期（病例组）。随后，使用限制性片段长度多态性 (RFLP) 技术对 FBLN5 的遗传多态性进行分析。 结果：本研究共纳入 292 名女性。在单变量分析中，患者的妊娠、产次和阴道分娩以及文献中描述的数据与 POP 的发生有关。然而，二元逻辑回归后，家庭出生和年龄仍然是 POP 的独立危险因素。我们发现 FBLN5 多态性与 POP 的发生之间没有关联 (p = 0.371)。结论：FBLN5 多态性与巴西女性中 POP 的发生之间没有关联。
OBJECTIVE: Pelvic organ prolapse (POP) is a very frequent situation in our population that may lead to a significant decrease in patients' quality of life. Currently, we are looking for predictive factors for the development of POPs; thus, this study seeks to evaluate whether the Fibulin 5 polymorphism (FBLN5) is associated with the occurrence of POP.METHODS: This is a cohort study with postmenopausal women who were divided into groups by POP stage: POP stages O and I (control group) and POP stages III and IV (case group). Subsequently, analyses of genetic polymorphisms of FBLN5 were performed using the Restriction Fragment Length Polymorphism (RFLP) technique.RESULTS: A total of 292 women were included in the study. Pregnancy, parity and vaginal delivery in the patients, as well as in data described in the literature, were related to the occurrence of POP in the univariate analysis. However, after binary logistic regression, home birth and age remained independent risk factors for POP. We found no association between the FBLN5 polymorphism and the occurrence of POP (p = 0.371).CONCLUSION: There was no association between the FBLN5 polymorphism and the occurrence of POP in Brazilian women.