Role of neurotrophic factors in the etiology and treatment of mood disorders
Role of neurotrophic factors in the etiology and treatment of mood disorders
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DOI：
10.1385/nmm:5:1:011
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发表时间：
2004-01-01
影响因子：
3.5
通讯作者：
Duman, RS
中科院分区：
文献类型：
--
作者：
Duman, RS
对啮齿动物的基础研究表明，暴露于压力会降低与抑郁症相关的大脑区域中脑源性神经营养因子（BDNF）的水平。相比之下，抗抑郁治疗会产生相反的效果，并阻止压力对脑源性神经营养因子的影响。BDNF上调和其他可能的神经营养/生长因子可以逆转或阻断在啮齿动物应激模型和抑郁患者中观察到的萎缩和细胞丢失。在抑郁症患者中观察到的形态学改变可能是由于胶质细胞和/或神经元的大小或数量减少，并可能包括成人神经发生的调节。本文综述了导致抑郁症和抗抑郁作用的神经营养假说的主要工作，以及这些作用的细胞机制和信号转导途径。
Basic research in rodents has demonstrated that exposure to stress decreases levels of brain-derived neurotrophic factor (BDNF) in brain regions associated with depression. In contrast, antidepressant treatment produces the opposite effect and blocks the effects of stress on BDNF. BDNF upregulation and possibly other neurotrophic/growth factors could reverse or block the atrophy and cell loss that has been observed in rodent stress models and in depressed patients. The morphological alterations observed in depressed patients could result from decreased size or number of glia and/or neurons and may include regulation of adult neurogenesis. This article reviews the primary work leading to a neurotrophic hypothesis of depression and antidepressant action and the cellular mechanisms and signal transduction pathways that underlie these effects.