Association of IL-6 174G/C (rs1800795) and 572C/G (rs1800796) polymorphisms with risk of osteoporosis: a meta-analysis
Association of IL-6 174G/C (rs1800795) and 572C/G (rs1800796) polymorphisms with risk of osteoporosis: a meta-analysis
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DOI：
10.1186/s12891-020-03334-x
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发表时间：
2020-05-28
影响因子：
2.3
通讯作者：
Li, Hong-zhuo
中科院分区：
文献类型：
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作者：
Chen, Bin;Li, Hong-zhuo
已有多项研究调查IL-6 174G/C （rs1800795）和572C/G （rs1800796）基因多态性与骨质疏松易感性之间的关系。然而，结果却相互矛盾。因此，我们进行了一项荟萃分析，旨在为IL-6基因多态性与骨质疏松症之间的关系提供更可靠的结果。方法采用PubMed、EMBASE、Cochrane Library和万方电子数据库进行检索。计算比值比（ORs）和95%置信区间（CIs），评估IL-6 174G/C （rs1800795）和572C/G （rs1800796）基因多态性与骨质疏松症风险的相关性。假阳性报告概率（FPRP）检验和威尼斯标准用于评估统计显著关联的可信度。结果本荟萃分析共纳入9项研究，共纳入1891例骨质疏松症患者和2027名健康对照。总体而言，IL-6 174G/C （rs1800795）基因多态性与骨质疏松易感性相关性不显著。对于IL-6 572C/G (rs1800796)， IL-6 572C/G加性模型（OR = 2.25, 95% CI: 1.55 ~ 3.26）、显性模型（OR = 1.42, 95% CI: 0.78 ~ 2.56）和隐性模型（OR = 1.96, 95% CI: 1.36 ~ 2.83）中骨质疏松易感性升高具有统计学意义。然而，IL-6 572C/ C等位基因被发现与骨质疏松易感性降低相关（OR = 0.76, 95% CI: 0.56-1.04）。当排除不符合HWE的研究时，结果没有显著变化。此外，当我们评估当前荟萃分析阳性结果的可信度时，我们在IL-6 572C/G隐性和可加性模型中发现了可信度较低的阳性结果。结论IL-6 572C/ ggg基因型可能与骨质疏松风险增加有关。
Background Several studies have been performed to investigate association between IL-6 174G/C (rs1800795) and 572C/G (rs1800796) gene polymorphisms and osteoporosis predisposition. However, the results were conflicting. So, we performed a meta-analysis designed to provide more reliable results for the association between IL-6 gene polymorphisms and osteoporosis. Methods Studies were searched using PubMed, EMBASE, the Cochrane Library and Wanfang electronic databases. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the association between IL-6 174G/C (rs1800795) and 572C/G (rs1800796) gene polymorphisms and osteoporosis risk. The false-positive report probabilities (FPRP) test and the venice criteria were used to assess the credibility of statistically significant associations. Results A total of 9 studies with 1891 osteoporosis patients and 2027 healthy controls were included in current meta-analysis. Overall, The IL-6 174G/C (rs1800795) gene polymorphism was insignificantly associated with osteoporosis vulnerability. For IL-6 572C/G (rs1800796), statistically significant elevated osteoporosis vulnerability was found in IL-6 572C/G additive model (OR = 2.25, 95% CI: 1.55-3.26), dominant model (OR = 1.42, 95% CI: 0.78-2.56) and recessive model (OR = 1.96, 95% CI: 1.36-2.83). However, the IL-6 572C/G C allele was found to be associated with reduced susceptibility to osteoporosis (OR = 0.76, 95% CI: 0.56-1.04). When excluding studies that did not conform to HWE, the results did not change significantly. Further, when we evaluated the credibility of the positive results of the current meta-analysis, we identified less credible positive results in IL-6 572C/G recessive and additive model. Conclusion In conclusion, IL-6 572C/G GG genotype may be associated with increased risk of osteoporosis.