Mapping of cortical activity in the first two decades of life: a high-density sleep electroencephalogram study.
Mapping of cortical activity in the first two decades of life: a high-density sleep electroencephalogram study.
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DOI：
10.1523/jneurosci.2532-10.2010
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发表时间：
2010-10-06
期刊：
影响因子：
--
通讯作者：
Huber R
中科院分区：
文献类型：
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作者：
Kurth S;Ringli M;Geiger A;LeBourgeois M;Jenni OG;Huber R
非快速动眼睡眠 (NREM) 期间的脑电图 (EEG) 慢波活动 (SWA)（EEG 频谱功率在 1-4.5 Hz 频段）反映可塑性变化的证据越来越多。神经影像学研究对灰质发育的区域评估揭示了生命前三十年皮质成熟的后前轨迹。我们的目的是测试这种区域皮质成熟是否反映在睡眠 SWA 的区域变化中。我们评估了 55 名健康受试者（2.4 – 19.4 岁）的整夜高密度脑电图（128 通道），并评估了 NREM 睡眠地形与年龄相关的变化。与成人一样，我们观察到所有受试者睡眠脑电图功率的频率特定地形分布。然而，从儿童早期到青春期后期，头皮上显示最大 SWA 的位置经历了从后部区域到前部区域的转变。这种沿后前轴的移动仅出现在 SWA 频率范围内，并且在整个晚上保持稳定。睡眠期间 SWA 地形的变化与神经影像学研究结果平行，表明皮质成熟在后部区域早期开始，并向额叶皮层扩散。因此，SWA 可能反映了皮质成熟的基本过程。将来，睡眠 SWA 评估可能会用作检测皮质成熟异常的临床工具。
Evidence that electroencephalography (EEG) slow-wave activity (SWA) (EEG spectral power in the 1– 4.5 Hz band) during non-rapid eye movement sleep (NREM) reflects plastic changes is increasing. Regional assessment of gray matter development from neuroimaging studies reveals a posteroanterior trajectory of cortical maturation in the first three decades of life. Our aim was to test whether this regional cortical maturation is reflected in regional changes of sleep SWA. We evaluated all-night high-density EEG (128 channels) in 55 healthy human subjects (2.4 –19.4 years) and assessed age-related changes in NREM sleep topography. As in adults, we observed frequency-specific topographical distributions of sleep EEG power in all subjects. However, from early childhood to late adolescence, the location on the scalp showing maximal SWA underwent a shift from posterior to anterior regions. This shift along the posteroanterior axis was only present in the SWA frequency range and remained stable across the night. Changes in the topography of SWA during sleep parallel neuroimaging study findings indicating cortical maturation starts early in posterior areas and spreads rostrally over the frontal cortex. Thus, SWA might reflect the underlying processes of cortical maturation. In the future, sleep SWA assessments may be used as a clinical tool to detect aberrations in cortical maturation.