Ventriculocisternal cerebrospinal perfusion in unanesthetized fetal lambs.
Ventriculocisternal cerebrospinal perfusion in unanesthetized fetal lambs.
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未麻醉胎羔的脑室脑脊液灌注。
DOI：
10.1152/jappl.1981.50.4.880
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Richardson,BS
中科院分区：
文献类型：
--
作者：
Bissonnette,JM;Hohimer,AR;Richardson,BS
已经开发出在胎羊侧脑室内和枕大池中放置套管的方法。手术后3 - 7天，在子宫内未麻醉的羔羊中进行脑室系统灌注。以123微升/分钟灌注人工脑脊液（CSF）4-5小时，胎儿动脉O2压、CO2压、pH值、平均动脉血压或心率无变化。该制剂适用于测量胎儿中央CSF的净形成，也适用于产生胎儿CSF离子组成的变化。
Methods have been developed for the placement of cannulas in the lateral cerebral ventricle and cisternum magnum of the fetal lamb. Three to seven days after surgery, perfusion of the cerebral ventricular system was carried out in unanesthetized lambs in utero. Artificial cerebrospinal fluid (CSF) was perfused at 123 microliter/min for 4-5 h with no change in fetal arterial O2 pressure, CO2 pressure, pH, mean arterial blood pressure, or heart rate. The preparation is suitable for measurements of net formation of fetal central CSF and also for producing changes in the ionic composition of the fetal CSF.