THE OPTIC LOBE OF DROSOPHILA-MELANOGASTER .2. SORTING OF RETINOTOPIC PATHWAYS IN THE MEDULLA
THE OPTIC LOBE OF DROSOPHILA-MELANOGASTER .2. SORTING OF RETINOTOPIC PATHWAYS IN THE MEDULLA
复制标题
DOI：
10.1007/bf00318687
复制
发表时间：
1992-01-01
影响因子：
3.6
通讯作者：
FISCHBACH, KF
中科院分区：
文献类型：
--
作者：
BAUSENWEIN, B;DITTRICH, APM;FISCHBACH, KF
我们提出了对野生型黑腹果蝇视叶内高尔基体染色的柱状神经元的定量评估。这一分析揭示了延髓10个神经纤维层之间的整体连接模式，并证明了至少三条主要视觉通路的存在。通路1将髓质层M10连接到小叶板。这条通路的输入层是M1和M5。通路2将M9连接到小叶的浅层，而浅层又紧密地连接到小叶板。这条途径通过M2获得主要输入。通路1和2通过单极细胞L1(终止于M1和M5)或L2和T1(终止于M2)接受来自视网膜细胞R1-6的输入。这些通路的神经元通常有很小的树突区域。我们讨论了通路1和通路2可能在运动检测中起主要作用的证据。通路3将M8连接到小叶的深层。在M8中，来自M3(通路3a)或M4和M6(通路3b)的信息汇聚，这两个层分别从L3和R8或L4和R7获得主要输入。通路3中的一些神经元具有较大的树突区。我们认为它们可能参与了形状和颜色的计算。讨论了脊椎动物视觉系统中路径组织的可能类比。
We present a quantitative evaluation of Golgi-impregnated columnar neurons in the optic lobe of wild-type Drosophila melanogaster. This analysis reveals the overall connectivity pattern between the 10 neuropil layers of the medulla and demonstrates the existence of at least three major visual pathways. Pathway 1 connects medulla layer M10 to the lobula plate. Input layers of this pathway are M1 and M5. Pathway 2 connects M9 to shallow layers of the lobula, which in turn are tightly linked to the lobula plate. This pathway gets major input via M2. Pathways 1 and 2 receive input from retinula cells R1-6, either via the lamina monopolar cell L1 (terminating in M1 and M5) or via L2 and T1 (terminating in M2). Neurons of these pathways typically have small dendritic fields. We discuss evidence that pathways 1 and 2 may play a major role in motion detection. Pathway 3 connects M8 to deep layers of the lobula. In M8 information converges that is derived either from M3 (pathway 3a) or from M4 and M6 (pathway 3b), layers that get their major input from L3 and R8 or L4 and R7, respectively. Some neurons of pathway 3 have large dendritic fields. We suggest that they may be involved in the computation of form and colour. Possible analogies to the organization of pathways in the visual system of vertebrates are discussed.