Postmenopausal Hormone Therapy Increases Retinal Blood Flow and Protects the Retinal Nerve Fiber Layer
Postmenopausal Hormone Therapy Increases Retinal Blood Flow and Protects the Retinal Nerve Fiber Layer
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DOI：
10.1167/iovs.09-3710
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发表时间：
2010-05-01
影响因子：
4.4
通讯作者：
Lesk, Mark R.
中科院分区：
文献类型：
--
作者：
Deschenes, Micheline C.;Descovich, Denise;Lesk, Mark R.
目的。研究绝经后激素治疗 (HT) 是否会增加绝经后妇女 (PMW) 的视网膜和 ONH 血流量 (BF) 并保护 ONH 地形和视网膜神经节细胞的功能。雌二醇 (E-2) 治疗对视网膜组织灌注的影响也在绝经动物模型——卵巢切除大鼠中进行了研究。招募了 64 名健康 PMW，其中 29 名从未使用过 HT（空集 HT），其中 35 名自绝经开始以来一直使用过 HT（+HT）。测量一只眼睛的颞下视网膜动脉 (ITRA)、视乳头周围视网膜和 ONH 边缘的血流量。还测量了 ONH 立体测量参数和图形视网膜电图 (PERG)。在卵巢切除大鼠中，使用 BF 示踪剂 N-异丙基-p-[C-14]-碘苯丙胺 ([C-14]-IMP) 评估接受 E-2 (n = 7) 或安慰剂 (n = 5) 治疗的大鼠的视网膜组织灌注。 结果。与空setHT组相比，+HT组的ITRA BF显着更大（P = 0.006），整个ONH区域的边缘体积更大（P = 0.032），并且视网膜神经的边缘体积（P = 0.042）、高度变化轮廓（P = 0.011）、平均厚度（P = 0.033）和横截面积（P = 0.020）更大根据年龄、眼灌注压和初潮年龄进行调整后，ONH 颞下区域的纤维层。在卵巢切除大鼠中，E-2 治疗显着增加了视网膜灌注，范围为 22% 至 45%。结论。这些发现表明雌激素和 HT 增加视网膜血流量并保护视网膜神经纤维层。 （投资眼科可见科学。2010；51：2587-2600）DOI：10.1167/iovs.09-3710
PURPOSE. To investigate whether postmenopausal hormone therapy (HT) increases retinal and ONH blood flow (BF) and protects ONH topography and the function of retinal ganglion cells in postmenopausal women (PMW). The effect of estradiol (E-2) treatment on retinal tissue perfusion was also investigated in ovariectomized rats, an animal model for menopause.METHODS. Sixty-four healthy PMW were recruited, 29 of whom never used HT (empty setHT) and 35 of whom had used HT (+HT) continuously since the onset of menopause. Blood flow of the inferotemporal retinal artery (ITRA), peripapillary retina, and ONH rim were measured in one eye. The ONH stereometric parameters and the pattern electroretinogram (PERG) were also measured. In ovariectomized rats, the retinal tissue perfusion was assessed using the BF tracer N-isopropyl-p-[C-14]-iodo-amphetamine ([C-14]-IMP) in rats treated with either E-2 (n = 7) or placebo (n = 5).RESULTS. Compared with the empty setHT group, the +HT group presented significantly greater BF of the ITRA (P = 0.006), greater rim volume for the entire ONH region (P = 0.032), and greater rim volume (P = 0.042), height variation contour (P = 0.011), mean thickness (P = 0.033), and cross-sectional area (P = 0.020) of the retinal nerve fiber layer for the inferotemporal region of the ONH when adjusted for age, ocular perfusion pressure, and age at menarche. In ovariectomized rats, E-2 treatment significantly increased retinal perfusion in a range of 22% to 45%.CONCLUSIONS. These findings indicate that estrogens and HT increase retinal blood flow and protect the retinal nerve fiber layer. (Invest Ophthalmol Vis Sci. 2010;51:2587-2600) DOI: 10.1167/iovs.09-3710