Renal metabolism of uric acid in type I insulin-dependent diabetic patients: Relation to metabolic compensation
Renal metabolism of uric acid in type I insulin-dependent diabetic patients: Relation to metabolic compensation
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DOI：
10.1055/s-2007-979093
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发表时间：
1997-10-01
影响因子：
2.2
通讯作者：
Hernandez, J
中科院分区：
文献类型：
--
作者：
GonzalezSilicia, L;GarciaEstan, J;Hernandez, J
Patients with insulin-dependent diabetes mellitus and poor glycemic control show hypouricemia with hyperuricosuria. In the present study, we have evaluated whether a good glycemic control influences the renal handling of uric acid. Sixteen patients (8 male, mean age 22.4+/-7.2 years) were studied under two situations, poor glycemic control (glycemia > 11 mmol/L and HbA1c > 10%) and good glycemic control (glycemia < 6 mmol/L and HbA1 c < 8.5 %). A group of 16 normal subjects served as the control group (8 male, mean age 21.9 +/- 9.1 years). In the poor glycemic control phase, patients showed lower plasma uric acid levels (0.18 +/- 0.06 mmol/L) and higher fractional urinary excretion of uric acid (16.1 +/- 9.3%) than the controls (0.28 +/- 0.06 and 8.2 +/- 1.9%, respectively). When a good glycemic control was reached, plasma uric acid increased (0.22 +/- 0.05), but it was still lower than that of the controls and fractional excretion of UA was normalized. Plasma uric acid was inversely correlated to glycemia (r = - 0.34, p < 0.05) and to HbA1c (r = - 0.56, p
