Shigellosis update: advancing antibiotic resistance, investment empowered vaccine development, and green bananas.
Shigellosis update: advancing antibiotic resistance, investment empowered vaccine development, and green bananas.
复制标题
DOI：
10.1097/qco.0b013e32833da204
复制
发表时间：
2010-10
影响因子：
3.9
通讯作者：
Olortegui MP
中科院分区：
文献类型：
--
作者：
Kosek M;Yori PP;Olortegui MP
Shigella is the principal cause of clinical dysentery and an important cause of morbidity and mortality among children in impoverished regions. The purpose of this review is to present key findings in the areas of epidemiology, disease control, and treatment of shigellosis. Recent research activity has advanced the understanding of the epidemiology and host pathogen interactions. Increased investment and activity in the area of vaccine development has lead to a diversification of candidates and ongoing technical advances yet continues to yield disappointing results in clinical trials in endemic populations and among the most relevant age groups (children under two years of age). The description of the rapid spread of quinolone resistance requires monitoring to ensure appropriate case management, particularly in Southeast Asia. The evaluation of adjunctive nutritional therapy in endemic areas has supported the use of green bananas in shortening the duration of Shigella dysentery and persistent diarrhea due to Shigella as well as improving weight gain in early convalescence. Despite a great level in activity in basic sciences, there continues to be a large gap in the ability to translate these findings into disease control measures or therapeutic options for individuals living in areas in which shigellosis is endemic.
