Noise considerations for PET quantification using maximum and peak standardized uptake value.
Noise considerations for PET quantification using maximum and peak standardized uptake value.
复制标题
使用最大和峰值标准化摄取值进行 PET 定量时的噪声考虑因素。
DOI：
10.2967/jnumed.111.101733
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Wahl RL
中科院分区：
文献类型：
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作者：
Lodge MA;Chaudhry MA;Wahl RL
在使用18F-FDG PET进行的肿瘤缓解监测研究中，最大标准化摄取值（SUVmax）通常用作定量指标。虽然它有几个优点，由于其简单的测定，对图像噪声的影响，对单像素SUVmax的关注。在这项研究中，我们使用真实的患者数据测量了与SUVmax和密切相关的峰值SUV（SUVpeak）相关的偏倚和再现性方面，以提供真实的噪声背景。在20名18F-FDG肿瘤患者中，在单床位置上采集列表模式三维PET数据15分钟。对于每例患者，对数据进行分类，以形成2组图像：呼吸门控图像，使得每张图像的统计质量与3分钟/床位扫描相当，以及不同持续时间（1、2、3、4和5分钟）的5张统计独立（非门控）图像。根据重现性和偏倚分析肿瘤SUVmax和SUVpeak（定位12 mm直径球形感兴趣区域，以使封闭平均值最大化）。使用来自2个可比呼吸门控图像的配对SUV测量由于统计噪声（独立于生理和其他变量）导致的再现性分量。测量作为扫描持续时间的函数的偏差。重复肿瘤SUV测量的SUVmax和SUVpeak的患者内SD分别为5.6% ± 0.9%和2.5% ± 0.4%。1、2、3、4和5分钟图像的SUVmax平均正偏差分别为30%、18%、12%、4%和5%。SUV峰值也有偏差，但程度较小：1、2、3、4和5分钟图像分别为11%、8%、5%、1%和4%。当PET图像具有高统计质量时，SUVmax的优势得到最佳利用。对于通常与临床全身研究相关的具有噪声特性的图像，SUV峰值提供了一种稍微更强大的替代方案，用于评估肿瘤的代谢最活跃的区域。
In tumor response monitoring studies with 18F-FDG PET, maximum standardized uptake value (SUVmax) is commonly applied as a quantitative metric. Although it has several advantages due to its simplicity of determination, concerns about the influence of image noise on single-pixel SUVmax persist. In this study, we measured aspects of bias and reproducibility associated with SUVmax and the closely related peak SUV (SUVpeak) using real patient data to provide a realistic noise context. List-mode 3-dimensional PET data were acquired for 15 min over a single bed position in twenty 18F-FDG oncology patients. For each patient, data were sorted so as to form 2 sets of images: respiration-gated images such that each image had statistical quality comparable to a 3 min/bed position scan, and 5 statistically independent (ungated) images of different durations (1, 2, 3, 4, and 5 min). Tumor SUVmax and SUVpeak (12-mm-diameter spheric region of interest positioned so as to maximize the enclosed average) were analyzed in terms of reproducibility and bias. The component of reproducibility due to statistical noise (independent of physiologic and other variables) was measured using paired SUVs from 2 comparable respiration-gated images. Bias was measured as a function of scan duration. Replicate tumor SUV measurements had a within-patient SD of 5.6% ± 0.9% for SUVmax and 2.5% ± 0.4% for SUVpeak. SUVmax had average positive biases of 30%, 18%, 12%, 4%, and 5% for the 1-, 2-, 3-, 4-, and 5-min images, respectively. SUVpeak was also biased but to a lesser extent: 11%, 8%, 5%, 1%, and 4% for the 1-, 2-, 3-, 4-, and 5-min images, respectively. The advantages of SUVmax are best exploited when PET images have a high statistical quality. For images with noise properties typically associated with clinical whole-body studies, SUVpeak provides a slightly more robust alternative for assessing the most metabolically active region of tumor.