Evoked Potential as a Pain Evaluation Index for Neonatal Procedural Pain
Evoked Potential as a Pain Evaluation Index for Neonatal Procedural Pain
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DOI：
10.15344/2394-4978/2020/323
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发表时间：
2020-05
期刊：
影响因子：
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通讯作者：
Yui Shiroshita;H. Kirimoto;K. Nakagawa;Hiroko Uematsu;I. Sobue
中科院分区：
文献类型：
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作者：
Yui Shiroshita;H. Kirimoto;K. Nakagawa;Hiroko Uematsu;I. Sobue
频繁的疼痛对新生儿大脑和神经的发育、认知、运动和行为都有短期和长期的负面影响。住在新生儿重症监护病房的新生儿每天经常接受多次痛苦的手术。足跟穿刺是采血过程中最常见的疼痛方式之一，但足跟穿刺的疼痛一直没有得到充分的控制。由于药物干预缺乏镇痛效果和安全性，人们正在寻找各种非药物干预组合来缓解新生儿足跟枪的疼痛。为了改善新生儿足跟枪的疼痛，经常使用由生理和行为指标混合组成的早产儿疼痛量表（PIPP）作为疼痛评估指标，但PIPP在新生儿疼痛评估方面存在一些问题，单独使用PIPP进行疼痛评估会干扰新生儿足跟枪疼痛缓解的发展。近年来，对于无法用语言表达疼痛的新生儿，足跟穿刺后的诱发电位（EP）作为一种客观定量评价疼痛的指标受到了广泛关注。EP可以检测到更剧烈的疼痛刺激，并可以随着生长发育对新生儿疼痛进行持续评估。基于ep的疼痛评估的发展促进了新生儿足跟枪疼痛缓解的发展。
Frequent pain has short- and long-term negative influences on the development of the brain and nerves and cognition, motion, and behavior of neonates. Neonates staying in the Neonatal Intensive Care Unit frequently receive painful procedures many times a day. Heel lance is one of the most frequently performed painful procedures for blood sampling, but the pain of heel lance has been not sufficiently managed for a long time. Due to the lack of the analgesic effect and safety of pharmacological intervention, the pain relief for neonatal heel lance is being searched for in diverse combinations of non-pharmacological interventions. To develop pain relief for the heel lance, the Premature Infant Pain Profile (PIPP) comprised of a mixture of physiological and behavioral indices is frequently used as a pain evaluation index, but several problems of PIPP have been pointed out with regard to neonatal pain evaluation, and pain evaluation using PIPP alone interferes with the development of pain relief for neonatal heel lance. Recently, evoked potentials (EP) after heel lance have been attracting attention as an index of evaluating pain objectively and quantitatively for neonates unable to express pain with words. EP detects more sharply pain stimulation and may enable continuous evaluation of neonatal pain along with growth and development. The development of EP-based pain evaluation promotes the development of pain relief for neonatal heel lance.