Orientation of Turing-like Patterns by Morphogen Gradients and Tissue Anisotropies.
Orientation of Turing-like Patterns by Morphogen Gradients and Tissue Anisotropies.
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DOI：
10.1016/j.cels.2015.12.001
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发表时间：
2015-12-23
期刊：
影响因子：
9.3
通讯作者：
Megason SG
中科院分区：
文献类型：
--
作者：
Hiscock TW;Megason SG
在发育过程中周期性条纹的图案化需要控制条纹间距和方向的机制。许多模型可以解释条纹间距是如何控制的，包括分子机制，如图灵的反应扩散模型，以及基于细胞和力学的机制。然而，在这些情况下，条纹方向是如何控制的还知之甚少。在这里，我们使用一个简单但通用的周期性图案模型来模拟条纹取向，目的是找到与机制无关的条纹取向的定性特征。我们的模型预测了三类定性不同的取向机制：生产率的梯度、模型参数的梯度和各向异性(例如，扩散或生长)。我们提供的证据表明，我们的最小模型的结果也可以适用于更具体和复杂的模型，揭示了可能在各种生物系统中常见的条纹取向特征。
Patterning of periodic stripes during development requires mechanisms to control both stripe spacing and orientation. A number of models can explain how stripe spacing is controlled, including molecular mechanisms, such as Turing’s reaction-diffusion model, as well as cell-based and mechanical mechanisms. However, how stripe orientation is controlled in each of these cases is poorly understood. Here, we model stripe orientation using a simple, yet generic model of periodic patterning, with the aim of finding qualitative features of stripe orientation that are mechanism-independent. Our model predicts three qualitatively distinct classes of orientation mechanism: gradients in production rates, gradients in model parameters, and anisotropies (e.g. in diffusion or growth). We provide evidence that the results from our minimal model may also apply to more specific and complex models, revealing features of stripe orientation that may be common to a variety of biological systems.