To what extent can aphasic syndromes be localized?
To what extent can aphasic syndromes be localized?
复制标题
失语症在多大程度上可以被定位？
DOI：
10.1093/brain/116.6.1527
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
K. Poeck
中科院分区：
文献类型：
--
作者：
K. Willmes;K. Poeck
关于大脑皮层功能表征的现代观点使得人们很难坚持失语症的特定亚型与语言区域内的特定中枢相关的概念。我们对221例失语症患者进行了回顾性研究，这些患者在大脑中动脉区域有一个毗邻的血管病变。CT病变的定位建立在一个标准化的网格模型中。失语学数据基于亚琛失语症测试的一次或多次检查。这两组数据都在数据库和方法库系统中进行处理。失语症的类型和病变部位之间没有明确的联系。在一项较小的研究中，基底节，特别是尾状核头部参与了导致失语症的病变，这一点尚未得到证实。失语症中病变的定位概念必须考虑到在存在稳定病变的情况下失语症症状模式的变化，以及产生病变的神经状况的影响。
Modern views on the representation of function in the cortex make it difficult to maintain the notion that specific subtypes of aphasia are associated with specific centres within the language area. We have conducted a retrospective study on 221 aphasic patients with one contiguous vascular lesion in the territory of the middle cerebral artery. The localization of CT lesions was established within a standardized grid model. Aphasiological data were based on one or more examinations with the Aachen Aphasia Test. Both sets of data were processed in a data- and methodbase system. No unequivocal association between type of aphasia and localization of lesion was found. In a smaller study, participation of basal ganglia and in particular of the head of the caudate nucleus in lesions producing aphasia was not confirmed. Concepts of the localization of a lesion in aphasia must account for changes in patterns of aphasic symptoms in the presence of a stable lesion and for the impact of the neurological condition that has produced the lesion.