Tolerance, immunosuppression, and immune modulation: impacts on lung allograft survival.
Tolerance, immunosuppression, and immune modulation: impacts on lung allograft survival.
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DOI：
10.1097/mot.0000000000000871
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发表时间：
2021-06-01
影响因子：
2.2
通讯作者：
Kreisel D
中科院分区：
文献类型：
--
作者：
Shepherd HM;Gauthier JM;Kreisel D
肺移植后的免疫应答继续导致高比率的同种异体移植物失败和排斥，并且当前的免疫抑制不能解决肺的独特免疫学特性。在这里，我们回顾了最近的研究肺移植耐受和同种免疫，并讨论了免疫抑制的影响。同种异体肺移植物的耐受和同种免疫过程不同于其他实体器官。最近的研究表明，同种异体识别是在肺移植水平上调节的。此外，某些对肺同种异体移植物耐受性至关重要的细胞群可能促进其他器官的排斥反应。肺移植耐受的诱导与三级淋巴器官的形成有关，三级淋巴器官富含调节性T细胞，在预防排斥反应中起重要作用。最近的发现，关于同种异体激活和调节肺移植后的耐受性，介绍了令人兴奋的潜在途径，肺特异性免疫抑制的发展。
Immune responses following lung transplantation continue to result in high rates of allograft failure and rejection, and current immunosuppression does not address the unique immunologic properties of the lung. Here, we review recent studies on lung allograft tolerance and alloimmunity and discuss implications for immunosuppression. Processes governing tolerance and alloimmunity in lung allografts differ from other solid organs. Recent studies have suggested that allorecognition is regulated at the level of the lung graft. Furthermore, certain cell populations essential for lung allograft tolerance may facilitate rejection in other organs. Induction of lung allograft tolerance is associated with the formation of tertiary lymphoid organs, which are enriched in regulatory T cells and play an important role in preventing rejection. Recent discoveries regarding alloactivation and the regulation of tolerance following lung transplantation have introduced exciting potential avenues for the development of lung-specific immunosuppression.