Cue reactivity and its inhibition in pathological computer game players
Cue reactivity and its inhibition in pathological computer game players
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DOI：
10.1111/j.1369-1600.2012.00491.x
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发表时间：
2013-01-01
影响因子：
3.4
通讯作者：
Wuestenberg, Torsten
中科院分区：
文献类型：
--
作者：
Lorenz, Robert C.;Krueger, Jenny-Kathinka;Wuestenberg, Torsten
尽管病理性电脑游戏的社会相关性不断上升，但这种成瘾样行为障碍和物质相关成瘾的神经生物学基础是否具有可比性仍不清楚。在与物质相关的成瘾中，经常观察到注意力偏差和提示反应。我们使用点探针范式对八名男性病理性电脑游戏玩家 (PCGP) 和九名健康对照 (HC) 进行了一项功能性磁共振研究，其中包括短呈现（注意偏差）和长呈现（提示反应性）试验。与电脑游戏相关和中性的计算机生成的图片，以及来自国际情感图片系统的具有积极和中性效价的图片作为刺激。 PCGP 对游戏相关刺激和具有正效价的情感刺激表现出注意偏差。相比之下，HC 根本没有表现出注意力偏差效应。与 HC 相比，PCGP 在短呈现试验中在内侧前额叶皮层 (MPFC) 和前扣带回以及在舌回的长呈现试验中显示出更强的大脑反应。在一项探索性事后功能连接分析中，对于长演示试验，右额下回（与之前研究中的抑制处理相关）和 PCGP 中的提示反应相关区域（左眶额皮层和腹侧纹状体）之间的连接强度较高。我们观察到 PCGP 的行为和神经影响，与物质相关成瘾中发现的影响相当。然而，与提示相关的大脑反应取决于提示呈现的持续时间。与连接结果一起，这些发现表明自上而下的抑制过程可能会抑制长呈现试验中与提示反应性相关的神经活动。
Despite a rising social relevance of pathological computer game playing, it remains unclear whether the neurobiological basis of this addiction-like behavioral disorder and substance-related addiction are comparable. In substance-related addiction, attentional bias and cue reactivity are often observed. We conducted a functional magnetic resonance study using a dot probe paradigm with short-presentation (attentional bias) and long-presentation (cue reactivity) trials in eight male pathological computer game players (PCGPs) and nine healthy controls (HCs). Computer game-related and neutral computer-generated pictures, as well as pictures from the International Affective Picture System with positive and neutral valence, served as stimuli. PCGPs showed an attentional bias toward both game-related and affective stimuli with positive valence. In contrast, HCs showed no attentional bias effect at all. PCGPs showed stronger brain responses in short-presentation trials compared with HCs in medial prefrontal cortex (MPFC) and anterior cingulate gyrus and in long-presentation trials in lingual gyrus. In an exploratory post hoc functional connectivity analyses, for long-presentation trials, connectivity strength was higher between right inferior frontal gyrus, which was associated with inhibition processing in previous studies, and cue reactivity-related regions (left orbitofrontal cortex and ventral striatum) in PCGPs. We observed behavioral and neural effects in PCGPs, which are comparable with those found in substance-related addiction. However, cue-related brain responses were depending on duration of cue presentation. Together with the connectivity result, these findings suggest that top-down inhibitory processes might suppress the cue reactivity-related neural activity in long-presentation trials.