Satellite Transcripts Locally Promote Centromere Formation.

Satellite Transcripts Locally Promote Centromere Formation.
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卫星转录本局部促进着丝粒形成。

DOI:
10.1016/j.devcel.2017.07.017
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发表时间:
2017
期刊:
影响因子:
11.8
通讯作者:
Blower,MichaelD
Blower,MichaelD
中科院分区:
生物学1区
文献类型:
--
作者:
Perea-Resa,Carlos;Blower,MichaelD

文献摘要

相似文献

着丝粒转录是真核生物中常见的着丝粒特征,但目前还不清楚转录是如何与潜在的重复卫星序列相联系的。在这一期的《发育细胞》杂志中,McNynthal et al.(2017)显示,对于人类着丝粒,所有α-卫星序列都转录成染色质结合的RNA,并且是着丝粒组装所必需的。
Centromeric transcription is a common eukaryotic centromere feature, yet it is unclear how transcription is linked to underlying repetitive satellite sequences. In this issue ofDevelopmental Cell, McNulty et al. (2017) show for human centromeres that all α-satellite sequences are transcribed into chromatin-bound RNAs and are required for centromere assembly.