Beyond indigestion: emerging roles for lysosome-based signaling in human disease.
Beyond indigestion: emerging roles for lysosome-based signaling in human disease.
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DOI：
10.1016/j.ceb.2015.04.014
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发表时间：
2015-08
影响因子：
7.5
通讯作者：
Ferguson SM
中科院分区：
文献类型：
--
作者：
Ferguson SM
溶酶体日益被视为一个整合多种信号的枢纽，以控制细胞生理学的多个方面。越来越多定位于溶酶体的蛋白质被发现，它们对生长因子和营养物质可利用性的变化作出反应，从而调节mTORC1信号，以及MiT/TFE转录因子（MITF、TFEB和TFE3）被鉴定为在溶酶体和细胞核之间穿梭的蛋白质，以引发对溶酶体状态持续变化的转录反应，这些都说明了这一点。这些发现与人类遗传学的进展相平行，人类遗传学将参与溶酶体信号传导的基因突变与从癌症到神经系统疾病等广泛的人类疾病联系起来。本综述总结了在溶酶体细胞生物学和人类疾病之间的界面上的这些新发现。
Lysosomes are becoming increasingly recognized as a hub that integrates diverse signals in order to control multiple aspects of cell physiology. This is illustrated by the discovery of a growing number of lysosome-localized proteins that respond to changes in growth factor and nutrient availability to regulate mTORC1 signaling as well as the identification of MiT/TFE transcription factors (MITF, TFEB and TFE3) as proteins that shuttle between lysosomes and the nucleus to elicit a transcriptional response to ongoing changes in lysosome status. These findings have been paralleled by advances in human genetics that connect mutations in genes involved in lysosomal signaling to a broad range of human illnesses ranging from cancer to neurological disease. This review summarizes these new discoveries at the interface between lysosome cell biology and human disease.