Effects of hijiki feeding on arsenic distribution in rats administered large doses of arsenate
Effects of hijiki feeding on arsenic distribution in rats administered large doses of arsenate
复制标题
羊栖菜喂养对大剂量砷酸盐大鼠体内砷分布的影响
DOI：
10.1002/aoc.590080317
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发表时间：
1994
影响因子：
3.9
通讯作者：
K. Otsuki
中科院分区：
文献类型：
--
作者：
M. Katayama;Y. Sugawa;K. Otsuki
雄性大鼠喂食 5% Hijiki 海藻或 5% 纤维素两周，并在两天内给予大剂量砷酸钠 (Na2HAsO4) 7mg As kg−1 体重。在最后一次砷施用后 48 小时，分离并匀浆选定的器官。将股骨和粪便冻干；其中的一部分在研究核反应堆中受到热中子照射，并根据 76As 的感应伽马辐射确定了其中的砷浓度。在血细胞中检测到砷浓度最高。羊栖菜饮食组的尿液中砷含量高于纤维素饮食组。砷在各器官中的百分比分布表明，与砷酸盐给药后24小时的值相比，砷酸盐给药后48小时砷在血细胞中富集[M. Katayama 等人，应用。有机体。化学。 6 389 (1992)]。羊栖菜饮食比纤维素饮食更能加速砷在血细胞和股骨中的积累，羊栖菜饮食组其他器官（肝、心、肺和肾）的砷水平比纤维素饮食组下降得更快。
Male rats fed a diet of 5% Hijiki seaweed or 5% cellulose for two weeks were administered large doses of sodium arsenate (Na2HAsO4) 7mg As kg−1 of body weight, during two days. At 48 h following the last arsenic administration, selected organs were isolated and homogenized. Femur and feces were lyophilized; portions of them were irradiated with thermal neutrons in a research nuclear reactor and their arsenic concentrations were determined from the induced gamma radiation from 76As. The greatest concentration of arsenic was detected in blood cells. A greater arsenic level was found in urine from the Hijiki diet group than in that of the cellulose diet group. The percentage distribution of arsenic in various organs indicated that the arsenic concentrated in blood cells 48 h after the arsenate administration, in comparison with the value 24 h after the arsenate administration [M. Katayama et al., Appl. Organomet. Chem. 6 389 (1992)]. The Hijiki diet accelerated arsenic accumulation in blood cells and the femur more than the cellulose diet, and arsenic levels in other organs (liver, heart, lung and kidney) of the Hijiki diet group decreased faster than those from the cellulose diet group.