Rocio Virus: An Updated View on an Elusive Flavivirus.

Rocio Virus: An Updated View on an Elusive Flavivirus.
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DOI:
10.3390/v13112293
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发表时间:
2021-11-16
期刊:
Viruses
影响因子:
--
通讯作者:
Nogueira ML
Nogueira ML
中科院分区:
其他
文献类型:
--
作者:
Saivish MV;Gomes da Costa V;de Lima Menezes G;Alves da Silva R;Dutra da Silva GC;Moreli ML;Sacchetto L;Pacca CC;Vasilakis N;Nogueira ML

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罗西奥病毒(Rocio Virus,ROCV)是一种蚊媒黄病毒,也是人类的病原体。该病毒是巴西土生土长的病毒,1975年在圣保罗州首次发现,在两年多的时间里导致了沿海社区的几次脑膜脑炎流行,导致100多人死亡。绝大多数ROCV感染被认为是亚临床的,临床表现从不复杂的发热到致命的脑膜脑炎。鸟类是天然的储存库和放大宿主,ROCV在自然界中维持在蚊子-鸟-蚊子传播周期中,主要涉及Psorophora ferox蚊子。虽然自1976年以来,新城疫基本上没有被发现,但2011年,新城疫在盖阿S州重新出现,造成了一次有限的暴发。控制新城疫暴发有赖于可持续的病媒控制措施和公众教育。到目前为止,还没有特定的治疗方法或获得许可的疫苗。在这里,我们提供了生态、传播周期、流行病学、发病机制和治疗方案的概述,旨在提高我们理解、预测和理想地避免进一步出现ROCV的能力。
Rocio virus (ROCV) is a mosquito-borne flavivirus and human pathogen. The virus is indigenous to Brazil and was first detected in 1975 in the Sao Paulo State, and over a period of two years was responsible for several epidemics of meningoencephalitis in coastal communities leading to over 100 deaths. The vast majority of ROCV infections are believed to be subclinical and clinical manifestations can range from uncomplicated fever to fatal meningoencephalitis. Birds are the natural reservoir and amplification hosts and ROCV is maintained in nature in a mosquito-bird-mosquito transmission cycle, primarily involving Psorophora ferox mosquitoes. While ROCV has remained mostly undetected since 1976, in 2011 it re-emerged in Goiás State causing a limited outbreak. Control of ROCV outbreaks depends on sustainable vector control measures and public education. To date there is no specific treatment or licensed vaccine available. Here we provide an overview of the ecology, transmission cycles, epidemiology, pathogenesis, and treatment options, aiming to improve our ability to understand, predict, and ideally avert further ROCV emergence.
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