Zebrafish (Danio rerio) responds differentially to stimulus fish:: The effects of sympatric and allopatric predators and harmless fish
Zebrafish (Danio rerio) responds differentially to stimulus fish:: The effects of sympatric and allopatric predators and harmless fish
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DOI：
10.1016/j.bbr.2007.07.037
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发表时间：
2008-01-10
影响因子：
2.7
通讯作者：
Gerlai, Robert
中科院分区：
文献类型：
--
作者：
Bass, Stephanie L. S.;Gerlai, Robert
斑马鱼是发育生物学和遗传学的优秀模式生物。研究它的行为将增加对它的生物学已经很强的知识，并将加强这个物种在行为遗传学和神经科学中的应用。焦虑是人类最有问题的精神疾病之一。可以说，它的出现是异常夸大的自然恐惧反应的结果。斑马鱼可能是研究恐惧和焦虑生物学的合适模型。当动物暴露在捕食者面前时，恐惧反应就会表现出来，这些反应可以是后天的，也可以是天生的。在这里，我们调查了斑马鱼在第一次接触自然捕食者或其他鱼类时是否会对这些鱼类产生不同的反应。向幼稚的斑马鱼展示了根据捕食状态(捕食性或无害)和地理起源(异地或同域)选择的四种鱼类。我们的结果表明，NA：IVE斑马鱼对刺激性鱼类的反应是不同的。特别有趣的是斑马鱼的共域捕食者印度叶鱼引起的反捕食性反应，以及后者几乎没有表现出捕食性攻击的事实。这些发现开辟了一条新的研究途径，研究斑马鱼认为什么是“危险的”或引发恐惧。它们还将使我们能够开发与恐惧和焦虑相关的行为测试方法，用来分析基因对这些行为的贡献，或者新的抗焦虑物质对这些行为的影响。(C)2007 Elsevier B.V.保留所有权利。
The zebrafish has been an excellent model organism of developmental biology and genetics. Studying its behavior will add to the already strong knowledge of, its biology and will strengthen the use of this species in behavior genetics and neuroscience. Anxiety is one of the most problematic human psychiatric conditions. Arguably, it arises as a result of abnormally exaggerated natural fear responses. The zebrafish may be an appropriate model to investigate the biology of fear and anxiety. Fear responses are expressed by animals when exposed to predators, and these responses can be learned or innate. Here we investigated whether zebrafish respond differentially to a natural predator or other fish species upon their first exposure to these fish. Naive zebrafish were shown four species of fish chosen based on predatory status (predatory or harmless) and geographical origin (allopatric or sympatric). Our results suggest that na:ive zebrafish respond differentially to the stimulus fish. Particularly interesting is the antipredatory response elicited by the zebrafish's sympatric predator, the Indian Leaf Fish, and the fact that this latter species exhibited almost no predatory attacks. The findings obtained open a new avenue of research into what zebrafish perceive as "dangerous" or fear inducing. They will also allow us to develop fear and anxiety related behavioral test methods with which the contribution of genes to, or the effects of novel anxiolytic substances on these behaviors may be analyzed. (c) 2007 Elsevier B.V. All rights reserved.