A clinicopathologic study on the association of endometriosis and carcinoma of the ovary using a scoring system
A clinicopathologic study on the association of endometriosis and carcinoma of the ovary using a scoring system
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使用评分系统进行子宫内膜异位症与卵巢癌关联的临床病理学研究
DOI：
10.1046/j.1525-1438.1996.06010068.x
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
S. Silverberg
中科院分区：
文献类型：
--
作者：
T. Toki;S. Fujii;S. Silverberg
采用新设计的子宫内膜异位症评分系统对 235 例上皮性卵巢癌病例进行了研究，该评分系统包括临床和组织病理学结果，以评估与子宫内膜异位症的关联。所有评估的癌症中有 50 例 (21.3%) 被判断与子宫内膜异位症相关。子宫内膜异位症患者年龄较非子宫内膜异位症患者年龄明显早，临床分期明显早。主要的组织学亚型是透明细胞癌，子宫内膜异位症的组织学分级大多为1或2级。在 1 期和 2 期疾病中，与子宫内膜异位症相关的病例和无子宫内膜异位症的病例之间没有发现预后差异。总之，子宫内膜异位症与卵巢癌相关的实际频率比想象的要高，几乎一半的透明细胞癌肯定与子宫内膜异位症相关，并且卵巢癌与子宫内膜异位症相关的病例发生在较年轻的患者中，并且处于早期阶段和较低的组织学分级，但子宫内膜异位症的相关性似乎并不影响预后。
Two-hundred and thirty-five cases of epithelial ovarian carcinoma were studied with a newly devised scoring system for endometriosis consisting of both clinical and histopathologic findings, in order to evaluate the association with endometriosis. Fifty cases (21.3%) of all carcinomas evaluated were judged to be associated with endometriosis. The patients with endometriosis were younger and their clinical stage was significantly earlier than those without endometriosis. The predominant histologic subtype was clear cell carcinoma and the histologic grade was mostly 1 or 2 in the tumors with endometriosis. No prognostic difference was noted between the cases associated with endometriosis and those without endometriosis in stage 1 and 2 disease. In conclusion, the actual frequency of the association of endometriosis with ovarian carcinoma is higher than supposed and almost half of clear cell carcinomas are definitely related to endometriosis, and the cases of ovarian carcinoma associated with endometriosis occur in younger patients, and are of earlier stage and lower histologic grade, but the association of endometriosis does not seem to otherwise influence prognosis.