Cannabis use and suicide attempts among 86,254 adolescents aged 12-15 years from 21 low- and middle-income countries
Cannabis use and suicide attempts among 86,254 adolescents aged 12-15 years from 21 low- and middle-income countries
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DOI：
10.1016/j.eurpsy.2018.10.006
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发表时间：
2019-02-01
影响因子：
7.8
通讯作者：
Koyanagi, Ai
中科院分区：
文献类型：
--
作者：
Carvalho, Andre F.;Stubbs, Brendon;Koyanagi, Ai
背景：有证据表明，大麻的使用可能与青少年的自杀倾向有关。然而，很少有研究评估这种关联在低收入和中等收入国家（LMIC）。在这项横断面调查中，我们调查了21个LMICs的青少年中大麻使用和自杀企图的相关性，调整了潜在的混杂因素。方法：来自全球学校学生健康调查的数据分析了来自21个国家的86,254名青少年[平均（SD）年龄= 13.7（0.9）岁; 49.0%为女孩]。对过去一年的自杀企图和过去一个月和一生中的大麻进行了评估。结果：过去30天大麻使用的总患病率为2.8%，年龄-性别调整的患病率从0.5%（老挝）到37.6%（萨摩亚）不等，而一生大麻使用的总患病率为3.9%（范围0.5%-44.9%）。在过去一年中，自杀企图的总体发生率为10.5%。在对潜在混杂变量进行多变量调整后，过去30天吸食大麻与自杀未遂显着相关（OR = 2.03; 95%CI：1.42-2.91）。终生使用大麻也与自杀企图独立相关（OR = 2.30; 95%CI：1.74-3.04）。结论：我们的数据表明，大麻的使用与生活在中低收入国家的青少年自杀企图的可能性更大。应在前瞻性研究中证实/驳斥这种关联的因果关系，以进一步为中低收入国家预防自杀的公共卫生政策提供信息。(c)2018年Elsevier Masson SAS。All rights reserved.
Background: Evidence suggests that cannabis use may be associated with suicidality in adolescence. Nevertheless, very few studies have assessed this association in low-and middle-income countries (LMICs). In this cross-sectional survey, we investigated the association of cannabis use and suicidal attempts in adolescents from 21 LMICs, adjusting for potential confounders.Method: Data from the Global school-based Student Health Surveywas analyzed in86,254 adolescentsfrom 21 countries [ mean (SD) age = 13.7 (0.9) years; 49.0% girls]. Suicide attempts during past year and cannabis during past month and lifetime were assessed. Multivariable logistic regression analyses were conducted.Results: The overall prevalence of past 30-day cannabis use was 2.8% and the age-sex adjusted prevalence varied from 0.5% (Laos) to 37.6% (Samoa), while the overall prevalence of lifetime cannabis use was 3.9% (range 0.5%-44.9%). The overall prevalence of suicide attempts during the past year was 10.5%. Following multivariable adjustment to potential confounding variables, past 30-day cannabis use was significantly associated with suicide attempts (OR = 2.03; 95% CI: 1.42-2.91). Lifetime cannabis use was also independently associated with suicide attempts (OR = 2.30; 95% CI: 1.74-3.04).Conclusion: Our data indicate that cannabis use is associated with a greater likelihood for suicide attempts in adolescents living in LMICs. The causality of this association should be confirmed/refuted in prospective studies to further inform public health policies for suicide prevention in LMICs. (c) 2018 Elsevier Masson SAS. All rights reserved.