Intake suppression after hepatic portal glucose infusion: all-or-none effect and its temporal threshold.
Intake suppression after hepatic portal glucose infusion: all-or-none effect and its temporal threshold.
复制标题
肝门葡萄糖输注后的摄入抑制：全或无效应及其时间阈值。
DOI：
10.1152/ajpregu.1997.272.5.r1454
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Kaplan,JM
中科院分区：
文献类型：
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作者：
Baird,JP;Grill,HJ;Kaplan,JM
使用口内摄入试验评价了等渗葡萄糖肝门静脉输注对葡萄糖摄入量（3.2%）的影响，与传统试验不同，口内摄入试验允许在非剥夺大鼠中以明确的时间关系输注门静脉输注葡萄糖。在进餐开始前0、30、60或120分钟开始连续或不连续门静脉输注（0.1 ml/min）等渗葡萄糖或生理盐水。颈静脉输注等渗盐水或葡萄糖和门静脉输注等渗盐水没有效果。对于所有有效的门静脉葡萄糖输注，摄入量被抑制了约30%的基线值。由于有效门静脉葡萄糖输注的持续时间（和量）相差10倍，因此我们得出结论，在这些条件下，口内摄入抑制是全部或根本没有。是否获得摄入抑制更多地取决于何时输注，而不是输注多少。因此，在摄入试验前60至45分钟之间输注1.5 ml等渗葡萄糖是有效的，而在摄入试验前30分钟输注3.0 ml葡萄糖则无效。这些结果表明，肝脏参与控制未来的摄入量，但不参与终止正在进行的膳食。在分析肝脏对摄入控制的作用的代谢、激素和/或神经机制时，应考虑摄入抑制的时间要求。
The effects of hepatic portal infusions of isotonic glucose on glucose intake (3.2%) were evaluated with use of the intraoral intake test, which, unlike traditional tests, permits delivery of portal infusions in explicit temporal relationship to intake onset in nondeprived rats. Continuous or discontinuous portal infusions (0.1 ml/min) of isotonic glucose or saline were initiated 0, 30, 60, or 120 min before meal onset. Jugular infusions of isotonic saline or glucose and portal infusions of isotonic saline were without effect. For all effective portal glucose infusions, intake was suppressed by approximately 30% of baseline values. Because the duration (and quantity) of effective portal glucose infusions varied by a factor of 10, we conclude that intraoral intake suppression under these conditions is all or none in nature. Whether an intake suppression was obtained depended more on when the infusion was delivered than on how much was infused. Thus 1.5 ml of isotonic glucose infused between 60 and 45 min before the intake test was effective, whereas 3.0 ml infused for the 30 min before intake was without effect. These results suggest that the liver participates in the control of future intake but not in the termination of an ongoing meal. The temporal requirement for intake suppression should be considered in analyses of the metabolic, hormonal, and/or neural mechanisms that underlie the liver's contribution to intake control.