Impaired production of lymphokines and immune (gamma) interferon in the acquired immunodeficiency syndrome.
Impaired production of lymphokines and immune (gamma) interferon in the acquired immunodeficiency syndrome.
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获得性免疫缺陷综合征中淋巴因子和免疫（γ）干扰素的产生受损。
DOI：
10.1056/nejm198404053101404
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Roberts,RB
中科院分区：
文献类型：
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作者：
Murray,HW;Rubin,BY;Masur,H;Roberts,RB
为了研究使获得性免疫缺陷综合征（AIDS）患者易患机会性感染的细胞免疫缺陷，我们检测了16例患者的T淋巴细胞分泌巨噬细胞激活产物（淋巴因子）（包括γ干扰素）的能力。11例患者中有10例的单核细胞对丝裂原没有产生有效的淋巴因子，16例患者中有11例产生低于正常水平的γ干扰素（<300 U/ml）。此外，在用特异性微生物抗原刺激后，来自14名患者的细胞均不产生活性淋巴因子，并且来自13至14名患者的细胞完全不能分泌γ干扰素。然而，来自患者的单核细胞的抗微生物功能是完整的，并且一旦用正常淋巴因子或单独的γ干扰素刺激，来自患者单核细胞的巨噬细胞就以增强的和有效的细胞内抗微生物活性应答。这些结果表明，受损的淋巴因子的生产可能使艾滋病患者的机会性感染，他们提供了一个使用γ干扰素作为免疫治疗的理由。（N Engl J Med 1984;310：883-9。）
To examine the cellular immune defect that predisposes patients with the acquired immunodeficiency syndrome (AIDS) to opportunistic infections, we tested T lymphocytes from 16 patients for the capacity to secrete macrophage-activating products (lymphokines) including gamma interferon. Mononuclear cells from 10 of 11 patients did not generate an effective lymphokine in response to mitogen, and 11 of 16 produced subnormal levels of gamma interferon (<300 U per milliliter). In addition, upon stimulation with specific microbial antigen, cells from none of 14 patients generated active lymphokines, and cells from 13 to 14 completely failed to secrete gamma interferon. However, the antimicrobial function of monocytes from the patients was intact, and once stimulated with normal lymphokines or gamma interferon alone, macrophages derived from patients' monocytes responded with enhanced and effective intracellular antimicrobial activity. These results suggest that impaired lymphokine production may predispose patients with AIDS to opportunistic infections, and they provide a rationale for using gamma interferon as immunotherapy. (N Engl J Med 1984;310:883–9.)