Cellular senescence in skeletal disease: mechanisms and treatment.
Cellular senescence in skeletal disease: mechanisms and treatment.
复制标题
骨骼疾病中的细胞衰老：机制和治疗。
DOI：
10.1186/s11658-023-00501-5
复制
发表时间：
2023-10-27
影响因子：
8.3
通讯作者：
Shi, Qin
中科院分区：
文献类型：
--
作者：
He, Xu;Hu, Wei;Zhang, Yuanshu;Chen, Mimi;Ding, Yicheng;Yang, Huilin;He, Fan;Gu, Qiaoli;Shi, Qin
关键词：
肌肉骨骼系统支持整个身体的运动并提供血液生产，同时充当内分泌器官。随着年龄的增长，骨稳态的平衡被破坏，导致骨质流失和退行性疾病，如骨质疏松症、骨关节炎和椎间盘退变。骨骼疾病对老年人的运动和认知能力产生深远影响，从而给全球健康和经济带来重大挑战。细胞衰老是由各种基因毒性应激源引起的，并导致永久性细胞周期停滞，这被认为是衰老的潜在机制。在衰老过程中，衰老细胞（SnC）倾向于在骨骼中聚集，并通过释放衰老相关的分泌表型因子引发慢性炎症。多种信号通路参与调节骨和骨髓微环境中的细胞衰老。靶向 SnC 可以缓解与年龄相关的退行性疾病。然而，衰老与年龄相关疾病之间的关联仍不清楚。这篇综述总结了衰老在与年龄相关的骨骼疾病中的基本作用，强调了介导衰老的信号通路，并讨论了针对 SnC 的潜在治疗策略。
The musculoskeletal system supports the movement of the entire body and provides blood production while acting as an endocrine organ. With aging, the balance of bone homeostasis is disrupted, leading to bone loss and degenerative diseases, such as osteoporosis, osteoarthritis, and intervertebral disc degeneration. Skeletal diseases have a profound impact on the motor and cognitive abilities of the elderly, thus creating a major challenge for both global health and the economy. Cellular senescence is caused by various genotoxic stressors and results in permanent cell cycle arrest, which is considered to be the underlying mechanism of aging. During aging, senescent cells (SnCs) tend to aggregate in the bone and trigger chronic inflammation by releasing senescence-associated secretory phenotypic factors. Multiple signalling pathways are involved in regulating cellular senescence in bone and bone marrow microenvironments. Targeted SnCs alleviate age-related degenerative diseases. However, the association between senescence and age-related diseases remains unclear. This review summarises the fundamental role of senescence in age-related skeletal diseases, highlights the signalling pathways that mediate senescence, and discusses potential therapeutic strategies for targeting SnCs.
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影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
6.2
作者：
Chandra, Abhishek;Lagnado, Anthony B.;Pignolo, Robert J.
通讯作者：
Pignolo, Robert J.
肌肉减少症：病因，营养方法和miRNA。
影响因子：
5.6
作者：
Cannataro R;Carbone L;Petro JL;Cione E;Vargas S;Angulo H;Forero DA;Odriozola-Martínez A;Kreider RB;Bonilla DA
通讯作者：
Bonilla DA
影响因子：
3.8
作者：
Alfonzo, Monica Correa;Al Saedi, Ahmed;Fulzele, Sadanand;Hamrick, Mark W
通讯作者：
Hamrick, Mark W