Vascular endothelial growth factor: Possible role in fetal development and placental function
Vascular endothelial growth factor: Possible role in fetal development and placental function
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DOI：
10.1016/s1071-5576(97)00025-7
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发表时间：
1997-07-01
期刊：
影响因子：
--
通讯作者：
Cheung, CY
中科院分区：
文献类型：
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作者：
Cheung, CY
血管内皮生长因子（VEGF）是一种具有强效渗透性的内皮细胞有丝分裂原。这种生长因子以几种亚型存在;大多数组织中最丰富的形式是VEGF（165）。不同的异构体在生物学功能上表现出差异。在发育过程中，VEGF在多种胚胎和胎儿组织中表达，在肺、肾和心脏中发现最高水平。血管内皮生长因子也在胎盘组织和胎膜中表达，并且这种表达随着妊娠的进展而增加。在胎儿心脏和胎盘中，VEGF的表达是由缺氧诱导的。已经鉴定了VEGF的两种受体，KDR和Flt-1。它们在血管内皮细胞中广泛表达，并且也在VEGF定位的胎盘组织中发现。在人类中，Flt-1似乎是主要受体，而在牛和绵羊中，KDR是表达的主要受体。整个妊娠期间胎盘组织中VEGF及其受体的存在强烈表明VEGF在妊娠期间胎盘血管功能的发育和维持中发挥重要作用。VEGF在胎膜和胎盘的胎儿表面的定位提高了VEGF可能参与羊水量和组成的调节的可能性。版权所有（C）1997由妇科调查协会。
Vascular Endothelial growth factor (VEGF) is an endothelial cell mitogen with potent permeability properties. This growth factor exists in several isoforms; the most abundant form present in most tissues is VEGF(165). The different isoforms exhibit differences in biologic function. During development, VEGF is expressed in multiple embryonic and fetal tissues, with the highest levels found in the lung, kidney, and heart. Vascular endothelial growth factor is also expressed in placental tissues and fetal membranes, and this expression increases with advancing gestation. In the fetal heart and placenta, VEGF expression is inducible by hypoxia. Two receptors, KDR and Flt-1, have been identified for VEGF. They are widely expressed in vascular endothelial cells and are also found in placental tissues where VEGF is localized. In humans, Flt-1 appears to be the predominant receptor, whereas in the cow and sheep, KDR is the major receptor expressed. The presence of VEGF and its receptors in placental tissues throughout gestation strongly suggests that VEGF plays an important role in the development and maintenance of placental vascular function during pregnancy. The localization of VEGF in fetal membranes and the fetal surface of the placenta raises the possibility that VEGF may be involved in the regulation of amniotic fluid volume and composition. Copyright (C) 1997 by the Society for Gynecologic Investigation.