Omega-3 fatty acids: mechanisms underlying 'protective effects' in atherosclerosis.
Omega-3 fatty acids: mechanisms underlying 'protective effects' in atherosclerosis.
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DOI：
10.1097/mol.0b013e3283616364
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发表时间：
2013-08
影响因子：
4.4
通讯作者：
Deckelbaum RJ
中科院分区：
文献类型：
--
作者：
Chang CL;Deckelbaum RJ
本文就n-3脂肪酸（FA）抑制动脉粥样硬化的机制和分子研究进展进行了综述。n- 3fa对动脉脂蛋白脂肪酶（LpL）水平的调节作用与动脉壁脂质沉积的变化有关。动脉壁中LpL的表达也与局部巨噬细胞介导的炎症过程有关。越来越多的证据表明，n- 3fa可以改善炎症，这是动脉粥样硬化发展的另一个关键因素，包括减少促炎细胞因子的产生。n- 3fa抑制动脉粥样硬化信号通路，调节炎症性白细胞的表型及其在动脉壁的募集。关于n- 3fa抗动脉粥样硬化作用的新的机制见解已经出现。这些研究可能有助于未来预防与动脉粥样硬化相关的死亡率和发病率的治疗进展。
This article provides an updated review on mechanistic and molecular studies relating to the effects of n-3 fatty acids (FA) on inhibiting atherogenesis. The effects of n-3 FA on modulating arterial lipoprotein lipase (LpL) levels link to changes in lipid deposition in the arterial wall. LpL expression in the arterial wall also relates to local macrophage-mediated inflammatory processes. Increasing evidence suggests that n-3 FA ameliorate inflammation, another key component in the development of atherosclerosis, including decreases in pro-inflammatory cytokine production. n-3 FA inhibit atherogenic signaling pathways and modulate the phenotypes of inflammatory leukocytes and their recruitment in the arterial wall. New mechanistic insights into the anti-atherogenic action of n-3 FA have emerged. These studies may contribute to future therapeutic advances in preventing mortality and morbidity associated with atherosclerosis.