Behavioral sensitization to drug stimulant effects in C57BL/6J and DBA/2J inbred mice.
Behavioral sensitization to drug stimulant effects in C57BL/6J and DBA/2J inbred mice.
复制标题
C57BL/6J 和 DBA/2J 近交小鼠对药物刺激作用的行为敏感性。
DOI：
10.1037//0735-7044.108.4.789
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发表时间：
1994
影响因子：
1.9
通讯作者：
Burkhart-Kasch,S
中科院分区：
文献类型：
--
作者：
Phillips,TJ;Dickinson,S;Burkhart-Kasch,S
令人上瘾的毒品的共同特征很难识别。这些药物的一个普遍作用是精神运动刺激。此外，反复暴露通常会导致对药物刺激作用的敏感化。本研究在C57BL/6J和DBA/2J近交系小鼠中评价了几种药物对药物的增敏作用。DBA/2J小鼠对乙醇和甲基苯丙胺有致敏反应，而C57BL/6J小鼠对吗啡和甲基苯丙胺有致敏反应。菌株对乙醇和吗啡诱导的敏感度与它们对这些药物的急性兴奋作用的敏感度密切相关；甲基苯丙胺则不是这样。DBA/2J和C57BL/6J小鼠对不同药物的相对敏感性并不一致，这表明对这些药物的刺激性和敏化反应可能至少是由部分不同的神经机制介导的。
Common features shared by addictive drugs have been difficult to identify. One ubiquitous effect of these drugs is psychomotor stimulation. Further, repeated exposure commonly results in sensitization to drug stimulant effects. This study evaluates sensitization to drugs from several drug classes in C57BL/6J and DBA/2J inbred strain mice. DBA/2J mice showed sensitized responses to ethanol and methamphetamine, whereas C57BL/6J mice developed sensitization to morphine and methamphetamine. Strain susceptibilities to ethanol-and morphine-induced sensitization closely paralleled their sensitivities to the acute stimulant effects of these drugs; this was not the case for methamphetamine. The relative sensitivities of DBA/2J and C57BL/6J mice were not consistent across drugs, suggesting that the stimulant and sensitized responses to these drugs may be mediated by at least partially divergent neural mechanisms.(PsycINFO Database Record (c) 2016 APA, all rights reserved)