Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator
Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator
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DOI：
10.1007/s004320000190
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发表时间：
2001-04-01
影响因子：
3.6
通讯作者：
Tsubura, A
中科院分区：
文献类型：
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作者：
Nakagawa, H;Kiyozuka, Y;Tsubura, A
白藜芦醇是葡萄和葡萄酒中天然存在的产物。研究了合成白藜芦醇对雌激素受体（ER）阳性（KPL-1和MCF-7）和阴性（MKL-F）人乳腺癌细胞系生长的影响。白藜芦醇在低浓度下引起ER阳性细胞系的细胞增殖（KPL-1，小于或等于22 μ M; MCF-7，小于或等于4 μ M），而在高浓度下（小于或等于44 μ M），它在所有三种检测的细胞系中引起细胞生长的抑制。生长抑制是由于细胞凋亡所看到的亚G1级分的外观。凋亡级联上调Bax和巴克蛋白，下调Bcl-x（L）蛋白，激活caspase-3。白藜芦醇（52-74 μ M）拮抗亚油酸（一种有效的乳腺癌细胞刺激剂）的作用，并抑制ER阳性和阴性细胞系的生长。因此，白藜芦醇可能是一种有前途的抗癌剂，用于乳腺癌依赖性和非依赖性乳腺癌，并可能减轻西式饮食中亚油酸的生长刺激作用。
Resveratrol is a naturally occurring product found in grapes and wine. The effect of synthetic resveratrol on the growth of estrogen receptor (ER)-positive (KPL-1 and MCF-7) and -negative (MKL-F) human breast cancer cell lines was examined. Resveratrol at low concentrations caused cell proliferation in ER-positive lines (KPL-1, less than or equal to 22 muM; MCF-7, less than or equal to4 muM) whereas at high concentrations (less than or equal to 44 muM) it caused suppression of cell growth in all three cell lines examined. Growth suppression was due to apoptosis as seen by the appearance of a sub-G1 fraction. The apoptosis cascade up-regulated Bax and Bak protein, down-regulated Bcl-x(L) protein, and activated caspase-3. Resveratrol (52-74 muM) antagonized the effect of linoleic acid, a potent breast cancer cell stimulator, and suppressed the growth of both ER-positive and -negative cell lines. Thus, resveratrol could be a promising anticancer agent for both hormone-dependent and hormone-independent breast cancers, and may mitigate the growth stimulatory effect of linoleic acid in the Western-style diet.