Magnetic resonance imaging of cartilage glycosaminoglycan: Basic principles, imaging technique, and clinical applications
Magnetic resonance imaging of cartilage glycosaminoglycan: Basic principles, imaging technique, and clinical applications
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DOI：
10.1002/jor.20482
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发表时间：
2008-03-01
影响因子：
2.8
通讯作者：
Maroudas, Alice
中科院分区：
文献类型：
--
作者：
Gray, Martha L.;Burstein, Deborah;Maroudas, Alice
许多新的治疗策略已经并正在开发，以预防、纠正或减缓骨性关节炎的进展。我们评估这些技术的有效性，或确定它们可能提供最大益处的情况的能力，关键取决于可以作为软骨当前或预测状态的替代物的诊断方法。在这里，我们主要围绕磁共振成像(MRI)技术的发展进行大量工作，以无创地成像关节软骨的糖胺聚糖(GAG)浓度。这些技术是基于糖胺多聚糖在软骨中产生固定电荷的概念。从钠核磁共振开始，以及随后基于质子核磁共振的延迟Gd增强软骨核磁共振(DGEMRIC)的发展，这些技术使得在体外或体内软骨中带电的GAG分布能够被“可视化”。DGEMRIC技术已被用于初步临床研究，以了解治疗策略和监测疾病，因此可以进行十年前不可能进行的研究。这一新的技术能力承诺加快有效疗法的开发，并将其集中在最成功的领域。(C)2007年整形外科研究会。由威利期刊出版公司出版。
Many new therapeutic strategies have been and are being developed to prevent, correct, or slow the progression of osteoarthritis. Our ability to evaluate the efficacy of these techniques, or to determine the situations for which they might provide the most benefit, critically depends on diagnostic measures that can serve as proxies for the present or predicted state of the cartilage. We focus here on a body of work surrounding the development of magnetic resonance imaging (MRI) techniques to noninvasively image the glycosaminoglycan (GAG) concentration of articular cartilage. These techniques are based on the concept of fixed charge in cartilage resulting from the glycosaminoglycans. Starting with sodium MRI, and the subsequent development of delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) based on proton MRI, these techniques permit "visualization" of the charged GAG distribution in cartilage in vitro or in vivo. The dGEMRIC technique has been used in preliminary clinical studies to understand treatment strategies and to monitor disease, and as such is allowing studies that a decade ago would have been impossible. This new technical capability offers the promises of speeding development of effective therapies and focusing their use in areas where they can be most successful. (C) 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.