PEYERS PATCHES - ENRICHED SOURCE OF PRECURSORS FOR IGA-PRODUCING IMMUNOCYTES IN RABBIT
PEYERS PATCHES - ENRICHED SOURCE OF PRECURSORS FOR IGA-PRODUCING IMMUNOCYTES IN RABBIT
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DOI：
10.1084/jem.134.1.188
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发表时间：
1971-01-01
影响因子：
15.3
通讯作者：
CEBRA, JJ
中科院分区：
文献类型：
--
作者：
CRAIG, SW;CEBRA, JJ
通过同种异体细胞转移，然后通过免疫荧光对供体免疫细胞进行定量，评估派尔氏集结、外周血和腘淋巴结细胞的增殖和分化潜力。研究发现，派尔氏集结细胞是高度富集的细胞来源，具有增殖和分化为产生 IgA 的免疫细胞的潜力，而且派尔集结细胞在用供体细胞接种受辐射受体兔的肠道时，能产生产生免疫球蛋白的细胞，比来自外周血或腘淋巴结的细胞更有效。
The proliferative and differentiative potential of Peyer's patch, peripheral blood, and popliteal lymph node cells was assessed by allogeneic cell transfer followed by quantitation of donor immunocytes by immunofluorescence. It was found that Peyer's patches are a highly enriched source of cells which have the potential to proliferate and differentiate into IgA-producing immunocytes and that the Peyer's patch cells are far more efficient in seeding the gut of irradiated recipient rabbits with donor cells that give rise to immunoglobulin-producing cells than cells from peripheral blood or popliteal lymph nodes.