Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake.
Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake.
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DOI：
10.1016/j.semcdb.2017.01.002
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发表时间：
2017-07
影响因子：
7.3
通讯作者：
Cerione RA
中科院分区：
文献类型：
--
作者：
French KC;Antonyak MA;Cerione RA
细胞外囊泡（extracellular vesicles，EV）是一种脂质双层封闭的结构，含有细胞脱落的各种生物分子，作为细胞间通讯的主要形式越来越受到重视。事实上，EV已被证明在几个生理过程以及癌症等疾病中发挥重要作用。EV停靠在受体细胞的表面上，在那里它们从细胞表面传递信号和/或将其内容物转移到细胞中以引起功能反应。EV对接和细胞吸收是关键但知之甚少的过程。在这里，我们专注于电动汽车停靠和转移其内容到细胞的机制。此外，我们强调这些发现可能为治疗干预提供新的途径。
Extracellular vesicles (EVs), lipid bilayer-enclosed structures that contain a variety of biological molecules shed by cells, are increasingly becoming appreciated as a major form of cell-to-cell communication. Indeed, EVs have been shown to play important roles in several physiological processes, as well as diseases such as cancer. EVs dock on to the surfaces of recipient cells where they transmit signals from the cell surface and/or transfer their contents into cells to elicit functional responses. EV docking and uptake by cells represent critical, but poorly understood processes. Here, we focus on the mechanisms by which EVs dock and transfer their contents to cells. Moreover, we highlight how these findings may provide new avenues for therapeutic intervention.