Vasoactive intestinal peptide attenuates cytochrome c translocation, and apoptosis, in rat hippocampal stem cells
Vasoactive intestinal peptide attenuates cytochrome c translocation, and apoptosis, in rat hippocampal stem cells
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DOI：
10.1016/s0304-3940(02)00254-9
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发表时间：
2002-06-14
影响因子：
2.5
通讯作者：
Said, SI
中科院分区：
文献类型：
--
作者：
Antonawich, FJ;Said, SI
虽然广泛分布在大脑中，但海马体是血管活性肠肽(VIP)水平集中的区域之一。本研究以大鼠海马区干细胞为研究对象，研究血管活性肠肽对撤除营养支持诱导的细胞凋亡的影响。在细胞凋亡的级联过程中，细胞色素c从线粒体转移到细胞质，激活caspase，导致细胞死亡。VIP以剂量依赖的方式减少细胞色素c的这种移位，并减少细胞凋亡。这表明VIP调节神经细胞的凋亡，可能有助于干细胞的动态平衡。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
While widely distributed in the brain, one area with concentrated levels of vasoactive intestinal peptide (VIP) is the hippocampus. In this study, rat hippocampal stem cells were used to examine VIP's effects on apoptotic cell death induced by withdrawal of trophic support. In the apoptotic cascade, the translocation of cytochrome c from the mitochondria to the cytoplasm activates caspases, resulting in cell death. VIP decreased this translocation of cytochrome c in a dose-dependent manner, and reduced apoptosis. This demonstrates that VIP regulates neuronal apoptosis and may contribute to stem cell homeostasis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.