Porous silica microshells from diatoms as biocarrier for drug delivery applications
Porous silica microshells from diatoms as biocarrier for drug delivery applications
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DOI：
10.1016/j.powtec.2011.04.023
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发表时间：
2012-06-01
影响因子：
5.2
通讯作者：
Losic, Dusan
中科院分区：
文献类型：
--
作者：
Aw, Moom Sinn;Simovic, Spomenka;Losic, Dusan
本发明提供了由被称为硅藻土或硅藻土（DE）的硅藻土化硅藻产生的多孔二氧化硅微壳（微粒）作为用于药物递送应用的天然药物载体的用途。本文研究了澳大利亚Mount Sylvia Diatomite Pty.（香港）的特征在于使用扫描电子显微镜，粒度测量，BET分析和X射线粉末衍射分析。为了证明基于硅藻的药物递送概念用于植入和口服药物递送，研究了吲哚美辛作为水难溶性药物的模型。结果显示硅藻二氧化硅用于药物递送应用的有效性，约22重量%载药量和两周以上的持续药物释放。药物从硅藻结构中的释放分为两个阶段：第一阶段是快速释放（超过6 h），这归因于药物在硅藻表面的沉积;第二阶段是缓慢持续释放（超过2周），具有零级动力学，这是从硅藻孔和内部中空结构中释放的结果。这些结果证实了基于硅藻二氧化硅的天然材料可以成功地用作口服和植入药物递送应用的生物载体，提供了相当大的替代合成二氧化硅基材料的潜力。皇冠版权所有（C）2011由Elsevier B. V.出版。保留所有权利。
The use of porous silica microshells (microparticles) generated from fossilised diatoms known as diatomite or diatomaceous earth (DE) as a natural drug carrier for drug delivery application is presented. The structure, morphology, particle size distribution, porosity, surface area and crystallinity of diatom microshells obtained from Australian mine (Mount Sylvia Diatomite Pty. Ltd.) were characterised using scanning electron microscopy, particle size measurements, BET analysis and X-ray powder diffraction analysis. To prove the drug delivery concept based on diatoms for implant and oral drug delivery, indomethacin as a model of water poorly soluble drug was investigated. Results show the effectiveness of diatom silica for drug delivery application, with about 22 wt.% drug loading capacity and sustained drug release over two weeks. Two steps drug release from diatom structures were observed: the first is rapid release (over 6 h) attributed to the surface deposited drug and the second is slow and sustained release over two weeks with zero order kinetics, as a result of release from diatom pores and internal hollow structure. These results confirm that natural material based on diatom silica can be successfully applied as a biocarrier for both oral and implant drug delivery applications, offering considerable potential to replace synthetic silica based materials. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.