Initial thyroid status and cardiovascular risk factors: The EPIC-Norfolk prospective population study
Initial thyroid status and cardiovascular risk factors: The EPIC-Norfolk prospective population study
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DOI：
10.1111/j.1365-2265.2009.03640.x
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发表时间：
2010-03-01
影响因子：
3.2
通讯作者：
Khaw, Kay-Tee
中科院分区：
文献类型：
--
作者：
Boekholdt, S. Matthijs;Titan, Silvia M.;Khaw, Kay-Tee
甲状腺状态影响心血管风险的几个方面，包括血脂水平和血压。甲状腺状态是否影响冠心病（CHD）和全因死亡率的风险仍然存在争议。平均随访时间为10个中心点6年。患者研究参与者为11554名男性和女性，年龄45-79岁，居住在英国的诺福克。测量基线心血管危险因素被记录，并在基线样本中测量促甲状腺激素（TSH）和游离甲状腺素（FT 4）浓度。进行回归分析，以评估甲状腺激素水平和心血管危险因素之间的关联。采用比例风险模型评估基线甲状腺状态下冠心病和全因死亡的风险。没有资料可供甲状腺治疗在follow-up.ResultsThyroid异常是常见的，特别是妇女。甲状腺功能异常与心血管疾病风险特征的改变有关。即使在正常范围内，男性和女性的甲状腺激素水平（TSH比FT 4更强）与血脂水平和血压相关。我们没有观察到亚临床甲状腺异常和冠心病或全因mortality.ConclusionsDespite甲状腺激素水平和心血管危险因素之间的关联显着关联，甲状腺状态与未来冠心病或全因死亡率的风险在这个大的队列没有统计学显着相关。
P>ContextThyroid status affects several aspects of cardiovascular risk profile, including lipid levels and blood pressure. Whether thyroid status affects the risk of coronary heart disease (CHD) and all-cause mortality remains controversial.DesignThe EPIC-Norfolk prospective population study. Mean follow-up was 10 center dot 6 years.PatientsStudy participants were 11 554 men and women aged 45-79 years, who were living in Norfolk, UK.MeasurementsBaseline cardiovascular risk factors were recorded and concentrations of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were measured in baseline samples. Regression analyses were performed to assess the association between thyroid hormone levels and cardiovascular risk factors. A proportional hazards model was used to estimate the risk of CHD and all-cause mortality by baseline thyroid status. No information was available on thyroid treatment during follow-up.ResultsThyroid abnormalities were common, particularly among women. Thyroid abnormalities were associated with an altered cardiovascular risk profile. Even within the normal range, thyroid hormone levels, TSH more strongly than FT4, were associated with lipid levels and blood pressure among both men and women. We did not observe a significant association between subclinical thyroid abnormalities and risk of CHD or all-cause mortality.ConclusionsDespite the association between thyroid hormone levels and cardiovascular risk factors, thyroid status was not statistically significantly associated with the risk of future CHD or all-cause mortality in this large cohort.