Finite Element Analysis on Nanomechanical Sensing of Cellular Forces
Finite Element Analysis on Nanomechanical Sensing of Cellular Forces
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DOI：
10.2116/analsci.32.1189
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发表时间：
2016-11
影响因子：
1.6
通讯作者：
Gaku Imamura;Kota Shiba;Genki Yoshikawa
中科院分区：
文献类型：
--
作者：
Gaku Imamura;Kota Shiba;Genki Yoshikawa
细胞力的检测在研究细胞的机械基础中起重要作用。由于纳米力学传感器可以直接检测表面应力，因此可以利用它们来检测细胞力。在本研究中，我们使用有限元分析（FEA）对纳米力学传感器进行定量模拟，以检测细胞力。我们专注于两种类型的纳米力学传感器：悬臂型传感器和膜型表面应力传感器（MSS）。发现当纳米力学传感器上的细胞同步其运动时，可以获得传感信号。为了有效检测纳米力学传感器上的细胞力，我们讨论了传感器表面涂层的优化方案。
Detection of cellular forces plays an important role in investigating the mechanical basis of cells. As nanomechanical sensors can directly detect surface stress, they can be utilized to detect cellular forces. In the present study, we perform quantitative simulations of nanomechanical sensors for the detection of cellular forces using finite element analyses (FEA). We focus on two types of nanomechanical sensors: a cantilever-type sensor and a membrane-type surface stress sensor (MSS). It is found that sensing signals can be obtained when cells on the nanomechanical sensors synchronize their motions. To effectively detect cellular forces on the nanomechanical sensors, we discuss the optimization scheme for a coating layer on the surface of the sensors.