Translating the epitranscriptome.
Translating the epitranscriptome.
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DOI：
10.1002/wrna.1375
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发表时间：
2017-01
影响因子：
7.3
通讯作者：
Erlacher, Matthias David
中科院分区：
文献类型：
--
作者：
Hoernes, Thomas Philipp;Erlacher, Matthias David
RNA修饰对于翻译机器提供准确和有效的蛋白质合成是必不可少的。尽管转运RNA（tRNA）和核糖体RNA（rRNA）修饰的重要性已经得到了很好的描述，并且几十年来一直没有受到质疑，但内部信使RNA（mRNA）修饰的重要性直到最近才被揭示出来。新的实验方法已经能够识别mRNA的非翻译区和翻译区中的数千个修饰位点。到目前为止，N6-甲基腺苷（m6 A）、假尿苷（pseudouridine，m1A）、5-甲基胞嘧啶（m5 C）和N1-甲基腺苷（m1A）在真核细胞中被鉴定，并且在一定程度上在原核细胞中被鉴定。这些mRNA修饰的几种功能以前已经报道过，但许多方面仍然难以捉摸。修饰可以是直接调节蛋白质合成的重要因素。通过编辑和修饰mRNA，基因组信息和RNA表达调控的潜在多样化是通用的，需要解决许多问题才能完全阐明mRNA修饰的作用。在此，我们总结并强调了一些关于各种共转录和转录后修饰的最新发现，描述了这些过程对基因表达的影响，重点是蛋白质合成。WIREs RNA 2017，8：e1375. doi：10.1002/wrna.1375有关本文的更多资源，请访问WIREs网站。
RNA modifications are indispensable for the translation machinery to provide accurate and efficient protein synthesis. Whereas the importance of transfer RNA (tRNA) and ribosomal RNA (rRNA) modifications has been well described and is unquestioned for decades, the significance of internal messenger RNA (mRNA) modifications has only recently been revealed. Novel experimental methods have enabled the identification of thousands of modified sites within the untranslated and translated regions of mRNAs. Thus far, N 6‐methyladenosine (m6A), pseudouridine (Ψ), 5‐methylcytosine (m5C) and N 1‐methyladenosine (m1A) were identified in eukaryal, and to some extent in prokaryal mRNAs. Several of the functions of these mRNA modifications have previously been reported, but many aspects remain elusive. Modifications can be important factors for the direct regulation of protein synthesis. The potential diversification of genomic information and regulation of RNA expression through editing and modifying mRNAs is versatile and many questions need to be addressed to completely elucidate the role of mRNA modifications. Herein, we summarize and highlight some recent findings on various co‐ and post‐transcriptional modifications, describing the impact of these processes on gene expression, with emphasis on protein synthesis. WIREs RNA 2017, 8:e1375. doi: 10.1002/wrna.1375 For further resources related to this article, please visit the WIREs website.
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影响因子：
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作者：
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