Functions, mechanisms, and therapeutic implications of METTL14 in human cancer.
Functions, mechanisms, and therapeutic implications of METTL14 in human cancer.
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DOI：
10.1186/s13045-022-01231-5
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发表时间：
2022-02-03
影响因子：
28.5
通讯作者：
He J
中科院分区：
文献类型：
--
作者：
Guan Q;Lin H;Miao L;Guo H;Chen Y;Zhuo Z;He J
RNA修饰在许多生物学功能中发挥着至关重要的作用，其异常调节与癌症的进展相关。其中，N6-甲基腺嘌呤（m6A）是最丰富的RNA修饰。甲基转移酶样14（METTL14）是m6A甲基化转移酶复合物的核心成分，参与m6A修饰的动态可逆过程。 METTL14既作为癌基因又作为抑癌基因调控多种癌症的发生和发展。 METTL14诱导的m6A水平异常与肿瘤的发生、增殖、转移和侵袭有关。迄今为止，METTL14在多种恶性肿瘤中的分子机制尚未得到充分研究。本文系统总结了METTL14作为癌症诊断新生物标志物及其在人类肿瘤中的生物学功能的最新研究进展，并探讨了其潜在的临床应用。这项研究旨在为癌症的靶向治疗和改善预后提供新思路。
RNA modification plays a crucial role in many biological functions, and its abnormal regulation is associated with the progression of cancer. Among them, N6-methyladenine (m6A) is the most abundant RNA modification. Methyltransferase-like 14 (METTL14) is the central component of the m6A methylated transferase complex, which is involved in the dynamic reversible process of m6A modification. METTL14 acts as both an oncogene and tumor suppressor gene to regulate the occurrence and development of various cancers. The abnormal m6A level induced by METTL14 is related to tumorigenesis, proliferation, metastasis, and invasion. To date, the molecular mechanism of METTL14 in various malignant tumors has not been fully studied. In this paper, we systematically summarize the latest research progress on METTL14 as a new biomarker for cancer diagnosis and its biological function in human tumors and discuss its potential clinical application. This study aims to provide new ideas for targeted therapy and improved prognoses in cancer.
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